Objective To evaluate the in vitro antimicrobial effects of cyclodextrin-complexed and uncomplexed Manuka honey on bacteria commonly associated with blepharitis, and in vivo rabbit eye tolerability of a cyclodextrin-complexed methylglyoxal (MGO) Manuka Honey microemulsion (MHME). Methods and analysis In vitro phase: Bacterial growth inhibition was assessed by area under the growth curve (AUC)...

Klebsiella oxytoca M5a1 has the capacity to transport and to metabolize alpha-, beta- and gamma-cyclodextrins. Cyclodextrin transport is mediated by the products of the cymE, cymF, cymG, cymD, and cymA genes, which are functionally homologous to the malE, malF, malG, malK, and lamB gene products of Escherichia coli. CymE, which is the periplasmic binding protein, has been overproduced and purif...

Trans-dehydrocrotonin has antiulcerogenic and antitumor activities. A complex of beta-cyclodextrin with dehydrocrotonin was developed to improve the delivery of dehydrocrotonin. Complex in solid state was evaluated using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM). X-ray diffraction and scanning elec...

A bundle-shaped nano-supramolecular assembly possessing numerous luminescent cyclodextrin-Tb polyads and photosensitizing C(60) units has been constructed through the end-to-end inclusion complexation of cyclodextrin cavities with C(60)s, and its properties have been comprehensively characterized. Further investigations on the luminescence properties of the cyclodextrin-Tb polyad and the bundle...

Sonochemical procedure was used to synthesize Co/β-cyclodextrin complex. For the first time, Fe/β-cyclodextrin complex also synthesized in alkaline media. Moreover, β-cyclodextrin modified by citric acid (CA) and reacted with metal salts under ultrasonic irradiation. The prepared catalysts were characterized using EDX, UV–vis FTIR analytical techniques. highest incorporation of into observed cr...

Cyclodextrins, even the 6-membered α-cyclodextrin, are approved in the various pharmacopoeias as pharmaceutical excipients for solubilizing and stabilizing drugs as well as for controlling drug release. Recently α-cyclodextrin has also been marketed as health food with beneficial effects on blood lipid profiles. However, the concentration of α-cyclodextrin used may be very high in these cases, ...

The unusual self-assembly in chloroform of a novel cyclodextrin-based [2]pseudorotaxane, composed of heptakis-2,6-di-O-methyl-3-O-acetyl-β-cyclodextrin and a viologen-containing linear component, is reported.

Soft attachment of streptavidin to β-cyclodextrin-modified pegylated SAMs was efficiently performed in a reversible and repetitive way via orthogonal bifunctional linkers involving streptavidin-biotin recognition and redox-driven multivalent host-guest (β-cyclodextrin-ferrocene) interactions.

Amphiphilic cyclodextrins have been synthesized with self-acylating reaction using vinyl esters in dimethylformamide. In the present study no base, catalyst, or enzyme was used, and the structural analyses using thin layer chromatography, nuclear magnetic resonance spectroscopy and mass spectrometry show that the cyclodextrin is substituted preferentially by one acyl moiety at the C2 position o...