We have utilized antibody probes to examine the expression of DNA topoisomerases I and II and chromosome scaffold protein Sc-2 in normal and transformed cells. Neither topoisomerase I nor Sc-2 shows significant fluctuations in content or stability across the cell cycle. In contrast, topoisomerase II undergoes significant cell cycle-dependent alterations in both amount and stability. As cells pr...

This chapter introduces the paradigm `Limit Cycle Walking'. This paradigm for the design and control of two-legged walking robots can lead to unprecedented performance in terms of speed, efficiency, disturbance rejection and versatility. This is possible because this paradigm imposes fewer artificial constraints to the robot's walking motion compared to other existing paradigms. The application...

This paper investigates whether adaptive learning and news shocks, operating in tandem, can generate business cycle dynamics that match the data. In doing so, this paper adopts expectational stability (“E-stability”) as a natural criterion for rationality: plausible equilibria should arise from an adaptive learning formulation where agents form forecasts from a correctly specified model whose p...

We consider a single-server cyclic polling system with three queues where the server follows an adaptive rule: if it finds one of queues empty in a given cycle, it decides not to visit that queue in the next cycle. In the case of limited service policies, we prove stability and instability results under some conditions which are sufficient but not necessary, in general. Then we discuss open pro...

spatio-temporal variability of throughfall (tf) has an important role on the biogeochemical processes,soil, watershed hydrology as well as the nutrient cycle in forests. spatial distribution and temporalstability of tf patterns by five individual persian oak trees (quercus brantii var. persica) in thezagros forests of western iran, ilam, was quantified. sixteen tf manual gauges were placed bene...

Because of inherent variability in all human cyclical movements, such as walking, running and jumping, data collected across a single cycle might be atypical and potentially unable to represent an individual's generalized performance. The study described here was designed to determine the number of successive cycles due to continuous, repetitive countermovement jumping which a test subject shou...

The ability of cells to maintain genomic integrity is vital for cell survival and proliferation. Lack of fidelity in DNA replication and maintenance can result in deleterious mutations leading to cell death or, in multicellular organisms, cancer. The purpose of this review is to discuss the known signal transduction pathways that regulate cell cycle progression and the mechanisms cells employ t...

p53 phosphorylation and association with proteins is implicated in its stability and activity. We have compared the association of DNA-bound and overall pools of p53 with murine double minute 2 (Mdm2), c-Jun NH2-terminal kinase (JNK), p300/CBP, and p14 ARF during cell cycle progression. Whereas DNA-bound p53 associates with JNK at G0-G1 and with Mdm2 and p300 during S and G2-M phases, the gener...

In the biped robot’s walking process, walking parameters have important influence on its stability. In this article we based on the ZMP criterion, using the relationship between ZMP and the support area to judge the walking stability. Calculate the size of stability margin to analyze the influence of parameters’ change on stability. By programming in MATLAB and simulating in ADAMS, get the effe...