We describe a case of plantar interdigital cutaneous melanoma in a 22-year-old woman who reported changes in a pigmented lesion during pregnancy. Diagnosis was late and evolution unfavourable. The purpose of this report is to draw the attention of dermatologists to the need for careful regular examination of melanocytic lesions in pregnant women, not ignoring possible changes as always physiolo...

Microscopic polyangiitis (MPA) is a systemic antineu-trophil cytoplasmic autoantibody (ANCA)-associated vasculitis that affects small-sized blood vessels, almost invariably affects the lungs and kidneys, and is often associated with cutaneous involvement. Antiphospho-lipid (aPL) antibodies, including anti-phosphatidyl-serine-prothrombin complex (anti-PS/PT) antibodies, are thought to activate e...

INTRODUCTION Sj€ ogren syndrome is a systemic autoimmune disease characterized by dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia). Common cutaneous manifestations of Sj€ ogren syndrome include xerosis, annular erythema, hypergammaglobulinemic purpura, and immunologic inflammatory conditions such as vasculitis (leukocytoclastic and urticarial). The clinical manifestations of vas...

Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. ...

Sir, Merkel-cell carcinoma (MCC) is a rare malignant tumour of the skin which is highly aggressive; frequent recurrences and distant spread are common (1). Behçet’s disease (BD) is a multisystem vasculitis, with oral and genital aphthous ulcers, cutaneous vasculitis, uveitis and arthritis as its main features (2). Association of BD with malignant tumours, mainly solid neoplasms, has been descri...

Levamisole-adulterated cocaine has increased in prevalence over the last decade and is known to be associated with antineutrophil cytoplasmic antibodies (ANCA). Dermatologic manifestations of levamisole exposure, including cutaneous vasculitis, are widely appreciated; less is known about its effects on the kidney. We report two cases of patients with a history of cocaine abuse and levamisole-in...

Cutaneous vasculitis can be classified as primary or idiopathic; or secondary, when it presents as a manifestation of connective tissue diseases, infections, drug reactions or malignancies. Although most of the idiopathic cases are self-limited and responsive to supportive measures and nonsteroidal anti-inflammatory drugs, potent immunosuppressants are sometimes required for the management of t...

Cutaneous manifestations of type 1 cryoglobulinemia are usually related to vascular occlusion by noninflammatory thrombosis; rarely is leukocytoclastic vasculitis seen in type 1 cryoglobulinemia. We report the case of a 64-year-old male who presented with isolated cutaneous leukocytoclastic vasculitis that was initially attributed to essential mixed cryoglobulinemia after thorough diagnostic ev...

BACKGROUND Aerococcus viridans organisms are Gram-positive cocci that are widely distributed in hospital environments and room air. These bacteria have infrequently been encountered as human pathogens causing bacteremia, endocarditis and urinary tract infections. The significance of these bacteria may be overlooked due to their fastidious growth, and they are often confused with other strains o...

A dministration of propylthiouracil therapy has been associated with a hypersensitivity syndrome that typically manifests as vasculitis. Most cases of propylthiouracil therapy– induced antineutrophil cytoplasmic antibody (ANCA) positivity react to perinuclear ANCA (p-ANCA). We describe a patient who presented with cutaneous manifestations of propylthiouracil therapy hypersensitivity vasculitis ...