Background: The wide and indiscriminate use of drugs has increased the incidence and the modes of presentation of cutaneous drug reaction. Adverse cutaneous drug reactions are common, comprehensive information about their incidence, severity and ultimate health effects are unavailable. Objective: To study and evaluate incidence of adverse cutaneous drug reaction (ACDR) at our tertiary care hosp...

INTRODUCTION Drug reaction with eosinophilia and systemic symptoms syndrome is a potentially life-threatening cutaneous hypersensitivity reaction characterized by extensive mucocutaneous eruption, fever, hematologic abnormalities including eosinophilia and/or atypical lymphocytosis, and extensive organ involvement. The drugs most often responsible for causing drug reaction with eosinophilia and...

BACKGROUND Hydroxychloroquine sulfate and other antimalarial drugs have been used successfully as adjunctive therapy for patients with cutaneous lesions of dermatomyositis over the past 20 years. An increased incidence of cutaneous reactions to hydroxychloroquine has been postulated to occur in patients with dermatomyositis. OBJECTIVE To determine if adverse cutaneous eruptions due to hydroxy...

Bullous eruptions in patients with underlying systemic lupus erythematosus (LE) can mimic toxic-epidermal necrolysis (TEN), a rapidly progressive mucocutaneous reaction usually associated with medication use. Differentiating between classic drug-induced TEN and TEN-like cutaneous LE is important but difficult. We report a series of 3 patients with pediatric systemic LE who were admitted with se...

In the evaluation of patients with a history of adverse cutaneous drug reactions, it is important to obtain a detailed medication therapy including over-the-counter drugs, herbal and neuropathic remedies. There are a significant number of offending drugs causing adverse cutaneous drug reactions. If we can find out the clinical pattern of drug reaction along with their risk and aggravating facto...

taxenes, platinum salts, L-asparaginase and monoclonal antibodies involving anaphylactic or anaphylactoid reactions. To date no desensitisation protocols have been published on third generation aromatase inhibitors like AN. In these case reports both patients referred late reactions to AN with mainly cutaneous symptoms. To clarify the underlying mechanism of these reactions, patch tests with 10...

A 72-year-old Chinese female presented with a rapidly progressing, generalised rash over a 2-week period. Her medical history includes hypertension for which nifedipine had been started 5 weeks earlier. She was otherwise well with no systemic symptoms. Physical examination showed annular, scaly, erythematous plaques with central clearing on her upper and lower limbs, neck, trunk, and back (Figs...

The group of severe cutaneous drug reactions with systemic symptoms includes several syndromes: toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS). These reactions occur several days to six weeks after introducing the incriminating drug. The skin and internal organs (liver, kidneys, ...

A young male patient used fixed dose combinations of different fluoroquinolones and nitroimidazoles several times in the last few years for self-treating repeated episodes of diarrhea and loose motion. Each time, he experienced fixed drug eruptions that increased in number and severity on subsequent occasions. Suspecting association between the drug and the rashes, the patient each time discont...

Abstract Drug eruptions are among the most common diseases of skin. The majority cases benign and self-limited, however particular variants very severe potentially life threatening. A precise rapid diagnosis is essential but can be difficult in some instances as drug may lack specific histological criteria. Furthermore, pitfalls frequent heightened awareness to possible mimicry other skin requi...