spinal muscular atrophy (sma) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. the survival motor neuron (smn) protein level reduces in patients with sma. two different genes code survival motor neuron protein in human genome. skeletal and intercostal muscles denervation lead to weakness, hypotony, hyporeflexia, respiratory fa...

Objective: Leishmania recidivans is a chronic form of cutaneous leishmaniasis with characteristic picture. So the aim this study to record all cases leishmania that had history therapy by sodium stibogluconate. Patients and methods: This case series descriptive interventional therapeutic. Twenty-two patients clinical picture were included. All gave 2-4-month duration before time therapeutic inj...

Abstract Objective To investigate the cutaneous silent period (CSP) by measuring its onset latency, duration and amount signal suppression in patients with motor neuron disease (MND) grouped according to intensity of upper involvement (UMN), test effect contralateral hand contraction. Methods Painful stimulation was applied at V finger, contraction recorded from abductor digiti minimi (ADM) mus...

Spinal muscular atrophy (SMA) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. The survival motor neuron (SMN) protein level reduces in patients with SMA. Two different genes code survival motor neuron protein in human genome. Skeletal and intercostal muscles denervation lead to weakness, hypotony, hyporeflexia, respiratory fa...

conclusions intra-ophthalmic artery melphalan is an effective treatment for advanced cases of retinoblastoma, with a reasonable level of success. in the short follow up period of this study, it appears that the primary cases showed better results in the control of tumor. background the management of retinoblastoma remains a challenge to the multidisciplinary team, particularly as treatment affe...

BACKGROUND Lipoatrophic panniculitis (LP) is a rare disease of childhood characterized by eruption of tender erythematous nodules and plaques followed by circumferential bands of lipoatrophy often seen on the arms and legs. This condition has also been known as lipophagic panniculitis of childhood, annular atrophy of the ankles, and partial lipodystrophy. OBSERVATIONS A previously healthy 8-y...

Systemic elastorrhexis is a widespread hereditary degeneration of mesodermal tissues affecting many structures in the body, particularly the dermis, the media of the arteries, and Bruch's membrane in the eye. Pseudoxanthoma elasticum is one form of elastorrhexis mainly affecting the skin. Degeneration of the elastic lamina of Bruch's membrane results in the formation of angioid streaks in the r...

In progressive systemic sclerosis, sometimes referred to as generalized scleroderma, atrophic and sclerotic changes in the skin and internal organs are usually preceded by Raynaud's phenomenon. The disorder, which affects women more frequently than men, forms one of the socalled collagen vascular diseases and, although the aetiology is uncertain, there is evidence to suggest that auto-immune me...

BACKGROUND Cutaneous burn distant from skeletal muscles induces atrophy; however, its effect on muscle stem cells resident in skeletal muscle (satellite cells) distal to burn is not known. METHODS Satellite cell activation was measured in predominantly fast-twitch [tibialis anterior, extensor digitorum longus (EDL), plantaris, and gastrocnemius] and slow-twitch (soleus) muscles of rats that r...