In this paper, a boost converter with a clamp circuit is proposed for high intensity discharge (HID) lamp application. The clamp circuit provides zero voltage turn on for both main and clamp switches. Compared to conventional boost converters, the proposed converter has the following advantages: (i) high voltage gain without suffering from extreme duty ratio, (ii) low stress on the switches and...

objective: resveratrol, a phytoalexin, has a wide range of desirable biological actions. despite a growing body of evidence indicating that resveratrol induces changes in neuronal function, little effort, if any, has been made to investigate the cellular effect of resveratrol treatment on intrinsic neuronal properties. materials and methods: this experimental study was performed to examine the ...

Metrifonate, a cholinesterase inhibitor, has been shown to enhance learning in aging rabbits and rats, and to alleviate the cognitive deficits observed in Alzheimer's disease patients. We have previously determined that bath application of metrifonate reduces the spike frequency adaptation and postburst afterhyperpolarization (AHP) in rabbit CA1 pyramidal neurons in vitro using sharp electrode ...

Many cortical neurons and other vertebrate nerve cells are equipped with a persistent Na current, INaP, which operates at membrane potentials near the action potential threshold. This current may strongly influence integration and transduction of synaptic input into spike patterns. However, due to the lack of pharmacological tools for selective blockade or enhancement of INaP, its impact on spi...

Effects of the antiepileptic drug valproate on sodium and potassium currents in the nodal membrane of peripheral nerve fibers of Xenopus laevis were determined by voltage- and current-clamp experiments. Under voltage-clamp conditions, a reduction of both sodium and potassium conductance (in a ratio of 2:1) was observed. Typically, 2.4 mM (400 mg/L) valproate reduced the sodium current 54% and t...