The replacement problem for shock models under additive damage has been studied by many authors. They have considered the replacement problem where a system is replaced at damage, that have been derived the optimal policy for a cumulative damage model. The authors have considered the replacement problem where a system suffers two kinds of damage and is replaced preventively at age T or at the N...

This paper is concerned with opportunistic maintenance on a multi-component cumulative damage shock model with stochastically dependent components. A component fails when its cumulative damage exceeds a given threshold, and any such a failure creates a maintenance opportunity, and triggers a simultaneous repair on all the components, including the non-failed ones, such that damages accumulated ...

Objective: To demonstrate the association between various measures of spinal mobility and radiographic damage of the spine in individual patients with ankylosing spondylitis, and to determine whether the assessment of spinal mobility can be a proxy for the assessment of radiographic damage. Methods: Radiographic damage was assessed by the mSASSS. Cumulative probability plots combined the radiog...

OBJECTIVE To demonstrate the association between various measures of spinal mobility and radiographic damage of the spine in individual patients with ankylosing spondylitis, and to determine whether the assessment of spinal mobility can be a proxy for the assessment of radiographic damage. METHODS Radiographic damage was assessed by the mSASSS. Cumulative probability plots combined the radiog...

A multistage cancer model that describes the putative rate-limiting steps in carcinogenesis is developed and used to investigate the potential impact on cumulative lung cancer incidence of the hormesis mechanisms suggested by Feinendegen and Pollycove. In the model, radiation and endogenous processes damage the DNA of target cells in the lung. Some fraction of the misrepaired or unrepaired DNA ...

We analyze damage nucleation and localization in the random fuse model with strong disorder using numerical simulations. In the initial stages of the fracture process, damage evolves in an uncorrelated manner, resembling percolation. Subsequently, as the damage starts to accumulate, current enhancement at the tips of the microcracks leads eventually to catastrophic failure. We study this behavi...

OBJECTIVES To determine factors associated with damage accrual in a prospective cohort of patients with SLE. METHODS Patients with SLE who attended the Lupus Clinic at Monash Health, Australia, between 2007 and 2013 were studied. Clinical variables included disease activity (Systemic Lupus Erythematosus Disease Activity Index-2K, SLEDAI-2K), time-adjusted mean SLEDAI, cumulative glucocorticoi...