September 27, 2010, Milan, Italy. EOS S.p.A. (Ethical Oncology Science) announced today the initiation of the first-in-man trial of E-3810, its oral Dual Selective VEGF/FGF protein kinase inhibitor. Patients with advanced solid tumours not amenable to standard therapy will be recruited to this Phase I open-label, dose-escalation trial evaluating the safety profile of E-3810 in order to determin...

The aim of the procedure is to determine the optimal sampling times for the assessment of AUC after administration of a drug, either as a single dose or during a regular dosing schedule. For a single dose, AUC is defined as the total area under the plasma concentration time profile from time zero to infinity; for a regular dosing interval at steady state, AUC is defined as the area under the pl...

Brain tumor is one of the serious diseases so it is necessary to have accurate detection. Generally by using CTscan and MRI techniques visual examination is done by doctors for detection of part of brain having tumor. In this paper three algorithms are used to perform brain tumor segmentation of MRI image. In first stage image pre-processing is performed to remove file artifacts, skull removal ...

Pulmonary sarcomatoid carcinoma (PSC) is a rare malignant cancer composed of sarcoma and sarcoma-like elements with spindle or giant cell features. We report the case of a 60-year-old male with past medical history of right renal cell carcinoma 2 years earlier. Apulmonary nodule was detected in the left upper lobe, 23 months after nephrectomy. Systemic positron emission tomography-computerized ...

A 42-year-old asplenic woman was evaluated for a 2-week history of intermittent high-grade fevers and pleuritic chest pain and skin rash (figure 1). A CTscan of the chest showed multiple small nodules on both lungs (figure 2). Fungal serological studies were negative. A skin biopsy revealed palisading dermal granulomatous inflammation with focal vascular destruction and was negative for any org...

Background: Dose calculation algorithms play a very important role in predicting the explicit dose distribution. We evaluated the percent depth dose (PDD), lateral depth dose profile, and surface dose volume histogram in inhomogeneous media using calculation algorithms and inhomogeneity correction methods. Materials and Methods: The homogeneous and inhomogeneous virtual slab phantoms used in th...

introduction: the purpose of this work was to study the ability of mri normoxic polymer gel dosimetry for evaluating the dose distribution in hdr brachytherapy of esophagial cancer at imam reza brachytherapy center (mashhad, iran). materials and methods: initially, 2liters of normoxic gel (magic) was fabricated and then poured into 12 calibration test tubes and placed in a perspex walled phanto...

This study to evaluate the effect of hormone replacement therapy ( HRT ) and low-dose combinated oral pill on skin thickness , lipid profile and blood chemistry on menopausal woman.This study was carried out in one year randomized prospective study. 36 women were divided into 18 women receiving HRT and the other 18 receiving low-dose oral pill. The result of this study showed an increase in ski...