Purpose: CS-1008 (tigatuzumab; phase I/II), an antihuman death receptor 5 (DR5) agonist, induces apoptosis and has cytotoxic activity against human cancer cell lines. This study reports on the preclinical validation of In-labeled anti-DR5 humanized antibody CS-1008 as a diagnostic tool to study the DR5 occupancy in patients with cancer and establish dose ranges for receptor saturation kinetics ...

PURPOSE To determine whether narrowing of the oropharynx increases during relaxation in patients with severe obstructive sleep apnea syndrome. MATERIALS The study included 23 adult men in whom polysomnography had established a diagnosis of obstructive sleep apnea syndrome. Subjects had an average of 53 episodes of sleep apnea per hour, with each episode lasting 40 seconds or more. Oxygen satu...

UNLABELLED The aim of this study was to assess the volume and function of human brown adipose tissue (BAT) in vivo using MR imaging. METHODS BAT volumes under thermoneutral conditions in the cervical areas were assessed via water-fat contrast using the Dixon method and via water-saturation efficiency using fast spin-echo and T2-weighted images. The existence of cervical BAT was also assessed ...

A restricted earth fault (REF) protection element provides sensitive detection of ground faults near the neutral a transformer or generator. The sensitivity gains from REF are especially more valuable when equipment is low-impedance grounded phase differential (87T) ineffective. However, faces several challenges in systems, which becoming prevalent inverter-based resource (IBR) plants. Dependab...

A pilot study was performed to test the ability of MR to evaluate the brain lucencies shown by CT in Alzheimer disease patients and in normal control subjects. Eight patients with presumed Alzheimer disease and 47 normal controls, 12 over the age of 45 years and 35 under age 45, were studied. Each group included subjects with and without CT evidence of leukoencephalopathy. Inversion recovery, s...

STUDY OBJECTIVES To determine the ability of quantitative CT, with special reference to area of emphysema, to predict early postoperative oxygenation capacity and outcome after lung lobectomy for cancer. METHODS Sixty-two consecutive patients scheduled to undergo lung lobectomy for cancer were enrolled in this study. The area of emphysema (< - 910 Hounsfield units) was measured on a three-dim...

this study was conducted to investigate the effects of applying methods andamount of ammonium polyphosphate (0, 2 and 4 wt%) on fire retardancy andmechanical properties of wood flour/polypropylene composites. the resultsshowed that addition of fire retardant improved the mechanical properties such astensile and flexural strengths and fire retardancy of composites. but by increasingof fire retar...

High-resolution X-ray imaging combined with a steady-state flow experiment is used to demonstrate how pore-scale displacement affects macroscopic properties in an altered-wettability microporous carbonate, where porosity and fluid saturation can be directly obtained from the grey-scale micro-CT images. The resolvable macro pores are largely oil-wet average thermodynamic contact angle of 120°. p...

It is well established that shallow tillage (ST) and no-tillage (NT) of cultivated soils can have higher risk dissolved phosphorus (P) loss during runoff than conventional (CT). However, quantitative descriptors how differences in practices influence soil P sorption properties these turn remain lacking. Moreover, the on forms P, particularly molybdate unreactive (MUDP), has rarely been investig...

OBJECTIVES The aim of this study was to identify correlations between sleep apnea severity and tongue volume or posterior airway space measured via three-dimensional reconstruction of volumetric computerized tomography (CT) images in patients with obstructive sleep apnea (OSA) for use in predicting OSA severity and in surgical treatment. We also assessed associations between tongue volume and M...