In its recent guidance on bioequivalence, the U.S. Food and Drug Administration (FDA) recommends a two-sequence, four-period (2 x 4) replicated crossover design be used for assessment of population and individual bioequivalence [FDA. Guidance for Industry on Statistical Approaches to Establishing Bioequivalence; Center for Drug Evaluation and Research, Food and Drug Administration: Rockville, M...

The crossover behavior of various models exhibiting phase transition to absorbing phase with parity conserving class has been investigated by numerical simulations and cluster mean-field method. In case of models exhibiting Z_2 symmetric absorbing phases (the cellular automaton version of the nonequilibrium kinetic Ising model (NEKIMCA) and a stochastic cellular automaton invented by Grassberge...

As a model for chromosome aberrations, radiation-induced mitotic recombination of mwh and flr genes in Drosophila melanogaster strain (mwh +/+ flr) was quantitatively studied. Fission neutrons were five to six times more effective than X rays per unit dose in producing either crossover-mwh/flr twins and mwh singles-or flr singles, indicating that common processes are involved in the production ...