This paper presents an agent-based resource scheduling algorithm for Grid computing systems. With this scheduling algorithm, the computational resources of the Grid can be dynamically scheduled according to the real-time working load on each node. Thus a Grid system can hold an excellent load balance state. Furthermore, the application of this algorithm is introduced into the practical protein ...

<p style='text-indent:20px;'>Cross-docking is a kind of process that products are unloaded in front the inbound doors, consolidated based on downstream demand, and then directly transferred to outbound doors without long storage during transportation. In this paper, multi-door cross-dock truck scheduling problem investigated which sequencing assignment trucks need be considered, with obje...

Automated docking of drug-like molecules into receptors is an essential tool in structure-based drug design. While modeling receptor flexibility is important for correctly predicting ligand binding, it still remains challenging. This work focuses on an approach in which receptor flexibility is modeled by explicitly specifying a set of receptor side-chains a-priori. The challenges of this approa...

Docking, the initial association of secretory vesicles with the plasma membrane, precedes formation of the SNARE complex, which drives membrane fusion. For many years, the molecular identity of the docked state, and especially the vesicular docking protein, has been unknown, as has the link to SNARE complex assembly. Here, using adrenal chromaffin cells, we identify the vesicular docking partne...

Integrating Dock-Door Assignment and Vehicle Routing in Cross-Docking

The necessity of treating receptor flexibility in proteinligand docking has been widely acknowledged and is the subject of extensive research in the field of drug discovery [1]. The use of multiple discrete protein conformations, so-called ensemble docking, has been proven to be a valid concept to mimic target plasticity in docking experiments [2,3]. Using molecular dynamics (MD) the number of ...

انبارداری متقاطع یک سیستم توزیع است که در آن کالاها با هدف آماده‌سازی ظرفیت کامل ماشین‌‌‌های حمل و کاهش هزینه نگهداری موجودی از تأمین‌کنندگان به مقاصد تقاضا جابه­‌جا ‌‌می‌شوند. مسئله زمان‌بندی اخیراً توسط بسیاری پژوهشگران موردمطالعه قرار گرفته، اما عمده این مطالعات موارد شرایط قطعی بوده است؛ درحالی‌که عدم­‌قطعیت‌ها فرآیند وجود دارد. پژوهش حاضر، مرتبط عملیات انبار مرکز لجستیک (میدان مرکزی میوه تر...

Stress-specific activation of the chaperone Hsp33 requires the unfolding of a central linker region. This activation mechanism suggests an intriguing functional relationship between the chaperone's own partial unfolding and its ability to bind other partially folded client proteins. However, identifying where Hsp33 binds its clients has remained a major gap in our understanding of Hsp33's worki...