Tablets with 250 mg of Rhodiola rosea L. extract disintegrating in less than 10 min were developed. The influence of the extract content and type of fillers and disintegrants on disintegration time and tablet hardness was evaluated. Type of the filler and the extract/filler ratio but not the type of disintegrant determined fast disintegration of the tablets. It was demonstrated that the extract...

Citrus kawachiensis peel (PCK), a new functional food material, may prolong the healthy life expectancy of aging populations. Tableting PCK could facilitate its worldwide distribution and consumption. A dosage form that is easy to swallow should be prepared for ease use by elderly. We investigated fabrication orally disintegrating (OD) tablets with required commercial strength disintegration ti...

Sertraline Hydrochlride, the selective serotonin reuptake inhibitor (SSRI) is widely used in treatment of depression. Though Sertraline Hydrochloride is well absorbed after oral dosing, there is a first pass metabolism leading to a reduced bioavailability of the drug (44%). Therefore, the present investigation is concerned with the development of Fast Dissolving Tablets of Sertraline Hydrochlor...

Purpose: A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible tablet. Methods: Crospovidone (CPV), a hydrophilic carrier was selected for SSD preparation on the basis of 89% in- vitro MLX adsorption, 19% hydrat...

Eplerenone, a BCS class II drug with low bioavailability and t1/2 of 3-6 hrs is primarily used to treat Congestive Heart Failure (CHF) hypertension. So, develop the biological performance solid dispersion along oral disintegrates was prepared by employing HP ?-Cyclodextrin ?-Cyclodextrin. Eplerenone dispersions were repared various carriers in varying ratios carrier respectively (0.5:1, 1:1 1.5...

Black cumin seed oil (MBJH) ( Nigella sativa L .) is a well-known herb with pharmacology activities such as anticancer and anti-thrombocytopenia. The limitation of MBJH has poor absorption when using oral dosage form. liquid SNEDDS (Self-nanoemulsifying drug delivery system) an alternative formulation. However, the disadvantage liquid-SNEDDS MJBH was interaction between active ingredients soft ...