BACKGROUND In the present investigation, an attempt was made to isolate starch from jackfruit seed powder and utilize it as a superdisintegrant to design fast dissolving tablets of irbesartan. METHODS Starch was isolated from jackfruit seeds via aqueous and alkali extraction processes and evaluated for its physicochemical properties, for phytochemical tests, and for acute toxicity studies. Ir...

Ebastine (EBS) is a non-sedating antihistamine with long duration of action. This drug has predominantly hydrophobic property causing low solubility and bioavailability. Surface solid dispersions (SSD) an effective technique for improving the dissolution rate poorly soluble drugs by using hydrophilic water insoluble carriers.
 The present study aims to enhance EBS surface dispersion techni...

In the present work, fast dissolving tablets of fexofenadine hydrochloride were designed with a view to enhance patient compliance by sublimation method. In this method, camphor was used as the subliming agent (upto 30% w/w), crospovidone and croscarmellose sodium (2-8% w/w) were used as superdisintegrants. Estimation of fexofenadine hydrochloride in the prepared tablet formulations was carried...

In order to improve the dissolution and oral bioavailability of valsartan (VST), and reduce the required volume for treatment, we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) composed of VST (80 mg), Capmul® MCM (13.2 mg), Tween® 80 (59.2 mg), Transcutol® P (59.2 mg), and Poloxamer 407 (13.2 mg). In the present study, by using Florite® PS-10 (119....

This study was concerned with the investigation of acute pharmacological responses (pharmacodynamics) including analgesic and anti-inflammatory effects of ketorolac tromethamine fast dissolving tablets prepared by direct compression method using 3% croscarmellose sodium as a superdisintegrant by applying tail flick test and carragenan induced rat paw edema test respectively. Also, the work aime...

The objective of the study is to formulate bilayer tablets consisting of atorvastatin calcium (AT) as an immediate release layer and nicotinic acid (NA) as an extended release layer. The immediate release layer was prepared using super disintegrant croscarmellose sodium and extended release layer using hydroxypropylmethyl cellulose (HPMC K100M). Both the matrix and bilayer tablets were evaluate...

A potent non-sulfhydryl prodrug, trandolapril is transformed into the active substance, trandolaprilat, in liver. For obese individuals with mild-to-moderate essential hypertension, Trandolapril effective and safe. The elimination t1/2 of trandolaprilat are approximately 6 hours 16–24 hours, respectively. goal present work to develop immediate release tablet using various superdisintegrants. Cr...

Objective: The study aimed to develop fast-dissolving films (FDFs) of the immunosuppressant drug tacrolimus monohydrate for sublingual administration, employing central composite design (CCD), improve its bioavailability. Methods: Tacrolimus: β-cyclodextrin inclusion complexes prepared earlier were formulated into FDFs. CCD was used developing optimal film formulation with desired characteristi...

The purpose of the present study was to develop oral dispersible tablets containing prednisolone (PDS)-loaded chitosan nanoparticles using microcrystalline cellulose (MCC 101), lactose, and croscarmellose sodium (CCS). The PDS-loaded chitosan nanoparticles were formulated by ionotropic external gelation technique in order to enhance the solubility of PDS in salivary pH. Prepared nanoparticles w...