BACKGROUND The number of eosinophils is increased in the mucosae of the digestive and the respiratory tracts in Crohn disease, even clinically quiescent. The mechanisms underlying this panmucosal eosinophilia are unknown. METHODS The response of blood eosinophils to various chemotactic agents was assessed in 15 patients with clinically quiescent Crohn disease. The results were compared with 1...

of terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted noncommercial use, distribution, and reproduction in any medium provided article is properly cited. a Department of Pathology and Laboratory Medicine – David Geffen School of Medicine – University of California, Los Angeles/CA – USA. b Department of Pathology and Laboratory Medicine – Weill Cornell Me...

35 INTRODUCTION C rohn’s disease is a chronic inflammatory disease of the gastrointestinal tract first described by Crohn, Ginzberg and Oppenheimer in 1932. Incidence of the disease is estimated at eight per 100,0000 with a prevalence of 170 per 100,000 (1). Transmural inflammation and lymphoid aggregates differentiate Crohn’s disease from ulcerative colitis and may occur in contiguous or class...

The role of the innate immunity in the pathogenesis of Crohn's disease (CD), an inflammatory bowel disease, is a subject of increasing interest. Neutrophils (PMN) are key members of the innate immune system which migrate to sites of bacterial infection and initiate the defence against microbes by producing reactive oxygen species (ROS), before undergoing apoptosis. It is believed that impaired ...

Crohn's disease has long been suspected of having a mycobacterial cause. Mycobacterium paratuberculosis is a known cause of chronic enteritis in animals, including primates, but may be very difficult to detect by culture. IS900 is a multicopy genomic DNA insertion element highly specific forM paratuberculosis. A polymerase chain reaction (PCR) based on the 5' region of IS900 and capable of the ...

BACKGROUND Iron deficiency anaemia is a frequent complication of Crohn disease. Treatment with ferrous iron (Fe2-) compounds is often unsatisfactory and is associated with gastrointestinal side effects. Theoretically, oral iron supplementation may even be harmful, because iron may reinforce intestinal inflammation by catalysing production of reactive oxygen species. We investigated the effect o...

From the Departments of *General Surgery, †General Pathology and ‡General Internal Medicine, Vernon Jubilee Hospital, Vernon, BC T he association of Crohn disease and adenocarcinoma of the small intestine and colon has been well established. However, malignant carcinoid of the small intestine associated with Crohn disease is rare. We describe the case of a patient with an incidental malignant c...

Perianal disease is a well-recognized complication of Crohn disease and is often present when diagnosis is made (1,2). The reported incidence of perianal Crohn disease in the pediatric population varies between 13% and 62% (3–6). Anorectal stricture is a less common manifestation, and rarely are symptoms noted unless complicated by perianal sepsis or fistulae (7,8). Genital involvement is rare ...

An investigation of immunological parameters was conducted in 38 patients with Crohn's disease. The immunological tests employed included skin tests with dinitrochlorobenzene and a battery of common skin test antigens, lymphocyte transformation with phytohaemagglutinin and pokeweed mitogen, serum immunoglobulins, and absolute lymphocyte counts. Crohn's disease patients were divided into two gro...