GM1 gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid b-galactosidase (b-gal), resulting in accumulation of ganglioside GM1 and its asialo-form (GA1) primarily in the brain. In this study, we investigated the effects of N-butyldeoxygalacto-nojirimycin (NB-DGJ), an imino sugar that inhibits ganglioside biosynthesis, in normal C57BL/6J (B6) and in b-gal knock...

Boron (B) is an essential microelement for higher plants, and its deficiency is widespread around the world and constrains the productivity of both agriculture and forestry. In the last two decades, numerous studies on model or herbaceous plants have contributed greatly to our understanding of the complex network of B-deficiency responses and mechanisms for tolerance. In woody plants, however, ...

application of soil conditioners for remediation of saline- sodic soils is one of the common methods for improving soil properties in arid and semi-arid regions. in order to study the effect of soil conditioners on retention of soil moisture content, an experiment was carried out based on randomized complete block design with three replications in a saline-sodic sandy clay loam soil. the treatm...

The pathogenesis of alcoholic pancreatitis is not fully understood. An increase in pancreatic digestive and lysosomal enzyme synthesis because of ethanol consumption could contribute to the development of pancreatic injury in alcoholics. This study aimed, firstly, to determine the effect of ethanol on the content and messenger RNA levels of pancreatic digestive enzymes and on the messenger RNA ...

OBJECTIVE The purpose of this trial was to compare three different iodine interventions. DESIGN School children aged 8-10 years were randomized into one of three groups: group A was provided with iodized salt by researchers with an iodine concentration of 25 ppm; group B purchased iodized salt from the market; and group C was similar to group B with the exception that they were given iodized ...

The adaptor protein TNF receptor-associated factor 3 (TRAF3) is a critical regulator of B lymphocyte survival. B cell-specific TRAF3 deficiency results in enhanced viability and is associated with development of lymphoma and multiple myeloma. We show that TRAF3 deficiency led to induction of two proteins important for glucose metabolism, Glut1 and Hexokinase 2 (HXK2). This was associated with i...

Pea plants, grown hydroponically, were supplied with different amounts of iron (Fe) ranging from complete deficiency to toxicity. Plant growth, chlorophyll and carotenoid content and chlorophyll fluorescence parameters were recorded at 7-day intervals from day 20 to day 41. Growth decrease, caused by Fe deficiency or excess as a rule accrued with strengthening and prolongation of the imposed st...