The goal of this review is to present a comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inherent implications for physiology and human pathology. Very recently, a series of new discoveries ...

We compared creatinine clearances determined by enzymatic (Kodak Ektachem 700 single-slide, Boehringer Mannheim creatinine PAP) and nonenzymatic (Jaffé, HPLC) methods with glomerular filtration rate measured by inulin clearance in patients with varying degrees of renal function. The Kodak enzymatic assay gave values for creatinine 2 to 3 mg/L higher than the other methods. This resulted in sign...

Plasma urea and creatinine concentrations and urea and creatinine clearances and excretion were measured in a sample of 40 infants of 25*5-33 weeks' gestation, birth weight 720-2000 g, between the ages of 0 5 and 33 days. Creatinine excretion rate was between 60 and 120 gmol/kg/day in the first five postnatal weeks (mean 90.5) and was independent of sex or growth retardation. This can be used i...

conclusions graft failure is more likely to occur in patients with higher serum creatinine levels. results there was a positive association between the serum creatinine level and graft failure (hr = 5.13, p < 0.001). a one unit increase in the serum creatinine level suggests an increased risk of graft failure of up to 5.13 times. the serum creatinine level significantly decreased over time (95%...

BACKGROUND Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a novel, sensitive and specific biomarker that is rapidly released after kidney injury. It predicts acute kidney injury (AKI) in multiple clinical scenarios. We hypothesized that urinary NGAL can predict AKI after liver transplantation. METHODS Urine was collected in 92 patients undergoing liver transplantation (18 living...

objective(s):to evaluate the effect of graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. materials and methods: animals were grouped into 6: group 1 received gum acacia, group 2 received g. pictum ethanol extract (300 mg/kg), group 3 received gentamicin, groups 4, 5, 6 received gentamicin along with g. pictum at...

BACKGROUND Clusterin is a glycoprotein which participates in a number of pathophysiological processes in the organism. Information about clusterin use in the diagnosis of nephropathy and the differential diagnosis of proteinuria has been published recently. AIM Search for correlations between urinary clusterin concentration and other renal function markers. Evaluation of urinary clusterin mea...

Background: Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocal...