OBJECTIVE Chronic Chlamydia pneumoniae (Cpn), Helicobacter pylori (Hp), and herpes virus infections have been associated with atherogenic serum lipid profile and an excess of cardiovascular events in adults. Because mechanisms leading to atherosclerosis are active since early childhood, we examined whether Cpn, Hp, or cytomegalovirus (CMV) seropositivity relates to serum lipid, lipoprotein, or ...

Abstract. The contribution of this paper is a tutorial in the use of BRITNeY animation tool together with CPN Tools to make different views on Coloured Petri Nets. Examples of such views are messagesequence charts, gantt-charts, or SceneBeans animations showing the state of the model. In this paper we will describe how to generate messagesequence charts from executions of Coloured Petri Nets an...

The aim of the present study was to express the recombinant Chlamydophila pneumoniae (C. pneumoniae) protein, Cpn 0810, in Escherichia coli (E. coli) BL21, and investigate the effects of Cpn 0810 on inflammatory and apoptotic processes in human monocytic (THP-1) cells. An ELISA was performed to detect the levels of the proinflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL...

In complex geometry the blowing-up operation amounts to replace a point in a space by the space of complex tangent lines through that point. It is a local operation which can be explicitly written down as follows. Consider the blow-up of Cn at the origin. This is the complex submanifold of Cn × CPn−1 C̃ ≡ {((z1, z2, · · · , zn), [w1, w2, · · · , wn])|(z1, z2, · · · , zn) ∈ [w1, w2, · · · , wn]}....

Autophagy in macrophages plays a key role in the pathogenesis and progression of atherosclerosis and has become a potential therapeutic target. Here we show that cordycepin (Cpn), a natural derivative of adenosine, markedly reduced atherosclerotic plaque and ameliorated associated symptoms such as dyslipidemia, hyperglycemia and inflammation in ApoE-/- mice. Supplementation of Cpn dose-dependen...

Two-dimensional CPN−1 models play an important role in quantum field theory because they share many properties with QCD. In particular, they possess instanton classical solutions and one can define topological charge and susceptibility in analogy with QCD. CPN−1 models represent therefore a useful theoretical laboratory to investigate numerical methods to be eventually applied to study the topo...

Denial of service attacks, viruses and worms are common tools for malicious adversarial behaviour in networks. Experience shows that over the last few years several of these techniques have probably been used by governments to impair the Internet communications of various entities, and we can expect that these and other information warfare tools will be used increasingly as part of hostile beha...

Software engineering methodologies rely on various and complex graphical representations and are more useful when associated to CASE tools designed to take care of constraints that have to be respected. However, such tools are complex to implement. This paper proposes some principles derived from the ECMA-NIST model for the conception of a generic CASE environment and outline how some major asp...

Contemporary business process simulation environments are geared towards design-time analysis, rather than operational decision support over already deployed and running processes. In particular, simulation experiments in existing process simulation environments start from an empty execution state. We investigate the requirements for a process simulation environment that allows simulation exper...