Partial hepatectomy (PH) triggers a rapid regenerative response in the remaining tissue to reinstate the organ function and the cell numbers. Among the molecules that change in the course of regeneration is an accumulation of prostaglandin E2 in the sera of rats with PH. Analysis of the cyclooxygenase (COX) isoenzymes in the remnant liver showed the preferential expression of COX-2 in hepatocyt...

tires represent a critical spare part in mines. there is a shortage of medium and large tires. in addition, with increased mining activities and the creation of new mines, the demand for tires has increased significantly. thus, it is particularly important for mining engineers to identify tire characteristics and correctly manage the spare part inventory. spare parts management is critical from...

Cox regression model serves as a statistical method for analyzing the survival data, which requires some options such as hazard proportionality. In recent decades, artificial neural network model has been increasingly applied to predict survival data. This research was conducted to compare Cox regression and artificial neural network models in prediction of kidney transplant survival. The prese...

Let m(z, θ) be a criterion function convex in parameter θ for every z. For a random sample Z1, . . . , Zn, the M-estimate θ̃ of θ minimizes the criterion function ∑n j=1 n −1m(Zj , θ). Suppose side information is available given by E(u(Z1)) = 0 for some square-integrable function u. In this article, we are concerned with the use of side information and propose to estimate θ by θ̂ which minimizes ...

Background: Two main issues that challenge model building are number of Events Per Variable and multicollinearity among exploratory variables. Our aim is to review statistical methods that tackle these issues with emphasize on penalized Lasso regression model.  The present study aimed to explain problems of traditional regressions due to small sample size and m...

HYPOTHESIS Although genetic changes associated with the progression to Barrett esophagus and adenocarcinoma have been identified, changes in gene expression associated with gastroesophageal reflux disease have not been reported. We examined expression levels of several genes important in carcinogenesis and compared expression levels with alterations in esophageal acid exposure. PATIENTS, DESI...

BACKGROUND Post-capillary pulmonary hypertension (pc-PH) is a disorder with elevated pulmonary arterial pressure and pulmonary vascular resistance (PVR) because of left heart disease (LHD), and is classified as reactive (PVR >2.5 WU) or passive (PVR ≤ 2.5 WU). However, the clinical significance of these pc-PH subtypes remains to be elucidated. METHODS AND RESULTS We examined 676 consecutive p...