نتایج جستجو برای: cox 2 inhibitory

تعداد نتایج: 2641865  

Journal: :Genome Biology 2003

Journal: :Endocrinology 2008
S K Banu J Lee V O Speights A Starzinski-Powitz J A Arosh

Endometriosis is a debilitating disease characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that affects up to 20% of women of child-bearing age. Cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the biosynthesis of prostaglandin E(2) (PGE(2)), is highly expressed in endometriotic tissues and results in increased concentrations of...

2017
Carla Fernandes Andreia Palmeira Inês I. Ramos Carlos Carneiro Carlos Afonso Maria Elizabeth Tiritan Honorina Cidade Paula C.A.G. Pinto M. Lúcia M.F.S. Saraiva Salette Reis Madalena M.M. Pinto

Searching of new enantiomerically pure chiral derivatives of xanthones (CDXs) with potential pharmacological properties, particularly those with anti-inflammatory activity, has remained an area of interest of our group. Herein, we describe in silico studies and in vitro inhibitory assays of cyclooxygenases (COX-1 and COX-2) for different enantiomeric pairs of CDXs. The evaluation of the inhibit...

2014
Tetsuo Kida Seiko Kozai Hiroaki Takahashi Mitsuyoshi Isaka Hideki Tokushige Taiji Sakamoto

PURPOSE To evaluate the pharmacokinetics and efficacy of topically applied nonsteroidal anti-inflammatory drugs (NSAIDs) in the retinochoroidal tissues of rabbits. METHODS The cyclooxygenase (COX) inhibitory activity of diclofenac, bromfenac, and amfenac, an active metabolite of nepafenac, were determined using human-derived COX-1 and COX-2. Each of the three NSAIDs was applied topically to r...

Journal: :Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale 2020

Journal: :American journal of physiology. Renal physiology 2004
Alex Paliege Diane Mizel Carmen Medina Anita Pasumarthy Yuning G Huang Sebastian Bachmann Josephine P Briggs Jurgen B Schnermann Tianxin Yang

It is well established that cyclooxygenase-2 (COX-2) and the neuronal form of nitric oxide synthase (nNOS) are coexpressed in macula densa cells and that the expression of both enzymes is stimulated in a number of high-renin states. To further explore the role of nNOS and COX-2 in renin secretion, we determined plasma renin activity in mice deficient in nNOS or COX-2. Plasma renin activity was ...

2015
Kay Brune Paola Patrignani

Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the cyclooxygenase (COX) isozymes, were discovered more than 100 years ago. They remain a key component of the pharmacological management of acute and chronic pain. The COX-1 and COX-2 isozymes have different biological functions; analgesic activity is primarily (although not exclusively) associated with inhibition of C...

Journal: :Molecular cancer therapeutics 2013
Raghavendra Gowda Subbarao V Madhunapantula Dhimant Desai Shantu Amin Gavin P Robertson

Melanoma is a highly metastatic and deadly disease. An agent simultaneously targeting the COX-2, PI3K/Akt, and mitogen-activated protein kinase (MAPK) signaling pathways that are deregulated in up to 70% of sporadic melanomas might be an effective treatment, but no agent of this type exists. To develop a single drug inhibiting COX-2 and PI3K/Akt signaling (and increasing MAPK pathway activity t...

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