The extracellular matrix (ECM) impacts stem cell differentiation, but identifying formulations supportive of differentiation is challenging in 3D models. Prior efforts involving combinatorial ECM arrays seemed intuitively advantageous. We propose an alternative that suggests reducing sample size and technological burden can be beneficial and accessible when coupled to design of experiments appr...

Desorption electrospray ionization (DESI) was coupled to an ambient pressure drift tube ion mobility time-of-flight mass spectrometer (IM-TOFMS) for the direct analysis of active ingredients in pharmaceutical samples. The DESI source was also coupled with a standalone IMS demonstrating potential of portable and inexpensive drug-quality testing platforms. The DESI-IMS required no sample pretreat...

We give nonequilibrium Green's function (NEGF) perspective on thermodynamics formulations for open quantum systems strongly coupled to baths. Scattering approach implying thermodynamic consideration of a super-system (system plus baths) weakly external super-baths is compared with system its analyze both approaches from the NEGF and argue that latter yields possibility formulation consistent dy...

Sildenafil citrate tablets (VIAGRA; Pfizer Inc) have been used since 1998 as an oral therapy for the treatment of erectile dysfunction. However, in some cases, patients may have difficulty in swallowing tablets, and the need to use water to aid in the oral administration of the tablets has the potential to interrupt the sexual encounter, reduce spontaneity, and therefore decrease the quality of...

In this article, we present and analyze the numerical stability of two coupled finite element formulations. The first one is $h$ - notation="LaTeX">$a$ -formulation well suited for modeling systems with super...

A comprehensive benchmarking study has been carried out to determine the influence of mesh formulation and chip separation methods on reliability accuracy finite element modelling large diameter drilling operations. The Coupled Eulerian–Lagrangian updated-Lagrangian (with deletion) formulations available in ABAQUS/Explicit, together with re-meshing) DEFORM 3D are compared by simulating through-...

We construct mesh-independent and parameter-robust monolithic solvers for the coupled primal Stokes--Darcy problem. Three different formulations their discretizations in terms of conforming nonconforming finite element methods volume are considered. In each case, robust preconditioners derived using a unified theoretical framework. particular, suggested utilize operators fractional Sobolev spac...

Self-healing systems represent an effective means of increasing the resilience cementitious structures, extending service life and reducing cement production. This is achieved through mitigation cracking related durability problems. The success a self-healing system critically dependent on selection appropriate healing agent, which depends upon specific application, as well number criteria incl...