Background: Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent registration trials risk suboptimal dosing that compromises statistical power and lowers the probability of technical success (PTS) for the investigational drug. While much methodological progress has been made toward adaptive dose-finding, and quantitative modeling of dose-response relationships...

Penelitian ini bertujuan untuk mengetahui perhitungan harga pokok produksi yang ada di UMKM Wisna Fresh Ponorogo pada periode 2021 bulan Februari sampai dengan April. Metode digunakan penelitian adalah metode full costing dan activity based dikembangkan dari seluruh data biaya dikeluarkan memproduksi produk UMKM, khusunya dilakukan oleh peneliti yaitu nugget ayam, tahu tuna, siomay ayam. Hasil ...

With the world still polarized between nations working to combat the effects of greenhouse gas emissions and those resistant to the idea, the UK commissioned a survey of the potential costs of ignoring possible changes. Sir Nicholas Stern, an economist within the British government's treasury, reported last month on his assessment of the challenge of climate change. He warns that it could cost ...

Ontario is the most populous of Canada's ten provinces with approximately 39% of the Canadian population. Its residents are eligible for provincially funded health coverage. The Ontario Ministry of Health and Long-Term Care, the Canadian Institute for Health Information, and CHIM Information Consulting Inc. (Canadian Health Information Management) jointly conducted a reabstraction study of 14,5...

This paper describes a hybrid technical-financial procedure for allocating cost in a large data center. It is designed as a modeling tool to permit IIWHAT-IF" analyses for various configurations, levels of costing. etc. The use of modular programming, independent tables, and matrix output allows the modeler maximum flexibility in allocating cost according to changing technical and financial con...

The demands and needs for cost information in psychiatric contexts have multiplied considerably in recent years, but have often been frustrated by inadequate data. The typical costs data available to the policy maker, manager, clinical professional or researcher have been dominated until recently by age-old accounting practices and line management arrangements, and constrained by fragmentation ...

A company’s profits may be defined as the positive difference between its income revenues and operational costs. Today, most companies use traditional costing methods and/or traditional Activity-Based Costing (ABC) to determine their operational costs with a view to direct operational and business process changes so that profits are realized. A tripartite approach is presented towards determini...