The cardiac metabolism of the fibrillating left ventricle of the dog heart with and without maintenance of left coronary artery inflow was investigated. During ventricular fibrillation without maintenance of coronary flow, myocardial adenosine triphosphate and glycogen fell progressively, and in vitro oxygen consumption of biopsied tissue initially increased, but with adequate coronary perfusio...

We determined the effect of heart rate on the disposition of neurally released norepinephrine from the cardiac tissues in open-chest, anesthetized dogs with complete atrioventricular block. After injecting desipramine to block the neuronal uptake of norepinephrine, we stimulated the cardiac sympathetic nerves supramaximally for about 3 minutes at a mean frequency of 2.7 Hz. In one series of exp...

transcatheter ablation of atrioventricular accessory pathway is the therapy of choice in symptomatic patients. the ablation of posteroseptal accessory pathways thas some important points due to its anatomical location. catheter ablation of posteroseptal accessory pathways via left side approach is time consuming with low success rate and higher complications. we performed successful transcathet...

AIMS To assess the effect of experimentally induced atrial fibrillation on coronary flow in humans. METHODS AND RESULTS In 16 patients (10 men, mean age 43+/-13 years) with normal coronary vessels, baseline and hyperaemic blood pressure and Doppler phasic coronary flow velocity were measured, using a 0.014 inch intracoronary Doppler flow wire, during sinus rhythm, experimentally induced atria...

Fig. 1. Transverse midesophageal plane at 458, demonstrating the short axis of the aortic valve in diastole. The ruptured aneurysm of the right coronary sinus protrudes into the right atrium just above the tricuspid valve producing the characteristic ‘windsock’ appearance described in textbooks. Colour-flow Successful surgical repair of a ruptured sinus of Valsalva aneurysm was performed in a 3...

Analysis of factors which may influence oxygen metabolism of the heart has received much attention since the early part of this century (1). Quantitative measurements of coronary blood flow and myocardial oxygen consumption (MVO,) have been accumulated from both human and animal studies (2, 3). These studies were uniformily concerned with adults, however, and virtually no information is availab...

BACKGROUND A growing population of patients lives with severe coronary artery disease not amenable to coronary revascularization and with refractory angina despite optimal medical therapy. Percutaneous reduction of the coronary sinus is an emerging treatment for myocardial ischemia that increases coronary sinus pressure to promote a transcollateral redistribution of coronary artery in-flow from...

Anatomic variations of the orifice of the human coronary sinus now have practical significance since the advent of catheterization of the coronary sinus. Six main types of variation of the valve of the coronary sinus of 150 hearts are described. The difficulties encountered in catheterization of the human coronary sinus are probably due to obstruction offered by large membranes, bars and networ...

In the experimental animal the basic and controversial problem was studied of the influence of cardiac contraction on coronary blood flow. Normally beating hearts were perfused at a constant pressure, and coronary inflow and outflow were determined. In order to assess the role of systole, prolonged periods of ventricular asystole and fibrillation were induced and observations were made of the c...

In the experimental animal the basic and controversial problem was studied of the influence of cardiac contraction on coronary blood flow. Normally beating hearts were perfused at a constant pressure, and coronary inflow and outflow were determined. In order to assess the role of systole, prolonged periods of ventricular asystole and fibrillation were induced and observations were made of the c...