نتایج جستجو برای: cornu ammonis

تعداد نتایج: 721  

Journal: :Journal of neurophysiology 2006
M Hutzler A Lambacher B Eversmann M Jenkner R Thewes P Fromherz

We report on the recording of electrical activity in cultured hippocampal slices by a multitransistor array (MTA) with 16,384 elements. Time-resolved imaging is achieved with a resolution of 7.8 microm on an area of 1 mm2 at 2 kHz. A read-out of fewer elements allows an enhanced time resolution. Individual transistor signals are caused by local evoked field potentials. They agree with micropipe...

Journal: :The Journal of clinical investigation 2005
Walter J Lukiw Jian-Guo Cui Victor L Marcheselli Merete Bodker Anja Botkjaer Katherine Gotlinger Charles N Serhan Nicolas G Bazan

Deficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline. Here we report that, in cytokine-stressed human neural cells, DHA attenuates amyloid-beta (Abeta) secretion, an effect accompanied by the formation of NPD1, a novel, DHA-derived 10,17S-docosatriene. DHA and NPD1 were reduced in Alzheimer disease (AD) hippocampal cornu ammonis re...

2004
Sheng-Tian Li Yasunori Saheki Yun-Fei Lu Kazuhito Tomizawa Hai-Yan Wu

Although memory deficits have been clearly documented in patients with human immunodeficiency virus type-1 (HIV-1) infection, the physiological basis of this dysfunction is poorly understood. We focused on Tat, a viral protein released from HIV-1–infected cells and investigated its effect on spatial learning in adult mice. An intracerebroventricular injection of Tat leads to attenuation of spat...

Abdoreza Sabahi Mohammad Hosseini-sharifabad,

Objective(s):The hippocampus has been implicated in pathophysiology of schizophrenia. Prenatal stress is a contributing risk factor for a wide variety of neuropsychiatric diseases including schizophrenia. This study examined long-term effects of prenatal restraint stress on the stereological parameters in the Cornu Ammonis (CA) of adult male rats as an animal model of schizophrenia. Materials ...

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