PURPOSE To evaluate the therapeutic efficacy of topical interleukin-1 receptor antagonist (IL-1Ra) in the treatment of dry eye disease. DESIGN Laboratory investigation. METHODS Dry eye disease was induced in C57BL/6 female mice through exposure to a desiccating environment within a controlled environment chamber. Topical formulations containing 5% IL-1Ra, 1% methylprednisolone, 0.05% cyclos...

Corneal disease is a significant cause of decreased vision or blindness in the horse worldwide. Numerous topical and systemic drugs over a prolonged period of time may be used to treat an equine corneal ulcer. Despite the high prevalence of corneal disease and ulceration in the horse, and the complexity of corneal wound healing, research is limited and more heavily devoted to in vivo studies wh...

Over the past ten years, corneal transplantation surgical techniques have undergone revolutionary changes. Since its inception, traditional full thickness corneal transplantation has been the treatment to restore sight in those limited by corneal disease. Some disadvantages to this approach include a high degree of post-operative astigmatism, lack of predictable refractive outcome, and disturba...

BACKGROUND Dry eye disease is a common debilitating ocular disease. Current diagnostic tests used in dry eye disease are often neither sensitive nor reproducible, making it difficult to accurately diagnose and determine end points for clinical trials, or evaluate the usefulness of different medications in the treatment of dry eye disease. The recently developed fluorophotometer can objectively ...

BACKGROUND Surgical outcome of corneal keloid is largely variable depending on reports, although surgical management is inevitable in visually significant cases. We here report clinical features, histopathological findings, and surgical outcome of four cases of corneal keloid. CASE PRESENTATION Four Korean male patients without a history of corneal trauma or disease were clinically and histol...

PURPOSE Idiopathic inflammation of the cornea, keratitis, has been proposed to result from an autoimmune process, but thus far no convenient animal model of keratitis exists. An attempt was made to establish an animal model for keratitis, to investigate possible autoimmune mechanisms. METHODS T-cell lines were established from lymph node cells removed from rats immunized with bovine corneal e...

The stroma of the human cornea has a slow tissue turnover rate and absorbs a large part of the ultraviolet light entering the eye. Also, the high demands of the eye’s optical system call for a very exact tissue organization in the corneal stroma. As a consequence, the cornea is potentially vulnerable to oxidative stress. The cytosolic copper-zinc superoxide dismutase (SOD1) [1] and the extracel...

Background: Global blindness is mainly due to Cataract, after this Corneal disease the major cause. For end stage corneal disease, only successful treatment by providing Osteo-Odonto-Kerato-Prosthesis (OOKP). The dental surgeon will play a vital role in surgeon. After extracting canine tooth from patient, places acrylic lamina centre of dentine (Dental Lamina) which acts like an ocular lens, la...

Purpose To demonstrate clearing of chronic corneal opacities and improvement of visual acuity with the use of BostonSight prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in ocular surface disease. Observations We undertook retrospective analysis of the medical records of a series of patients who underwent PROSE treatment from August 2006 to December 2014. Patients wer...

PURPOSE To investigate the clinical and genetic features of Korean patients with corneal dystrophies associated with mutations in the human transforming growth factor-β-induced (TGFBI) gene. METHODS In this study, 387 subjects (71 families and 89 individuals - 268 patients having TGFBI corneal dystrophies and 119 normal relatives) were assessed. All subjects underwent a complete ophthalmologi...