By comparing the composition of McCarey-Kaufman (MK) medium before and after corneal storage we attempted to identify specific physiological changes in the medium as predictors of tissue damage. We also tried to determine if hydrocortisone (a lysosomal membrane stabiliser) added to the medium could reduce tissue damage during storage. Corneas (human and rabbit) were stored in the MK medium with...

A summary of the fine structure of presumably normal cornea is presented and is augmented by details not previously published. Certain differences noted between epithelial and endothelial cells are discussed, in view of their possible bearing on the function of these layers. Corneal tissue obtained from patients afflicted loith keratoconus, cornea guttata, or Wilsons disease is compared with no...

Dendritic cells (DCs) regulate both innate and adaptive immune responses. In this article, we exploit the unique avascularity of the cornea to examine a role for local or very early infiltrating DCs in regulating the migration of blood-derived innate immune cells toward HSV-1 lesions. A single systemic diphtheria toxin treatment 2 d before HSV-1 corneal infection transiently depleted CD11c(+) D...

OBJECTIVE To determine the mean cornea power for this population and how it varies with gender and age. DESIGN A retrospective study. SETTING The eye clinic of the Niger Delta University Teaching Hospital. SUBJECTS All patients referred to the Optometric unit by the duty optometrist using a Carl Zeiss 599 Auto-refractokeratometer and the findings recorded in a register designed for that p...