The various elements of federalism as well as other aspects of state organisation are interrelated. The isolation or sealing off of any of these facets could limit the possibility for necessary cross-topic adjustments or trade-offs. Therefore, coordination is necessary and the approach ‘nothing is decided until everything is decided’ tends to be favourable. Key Messages Federalism and Peace Med...

Blow/Fill/Seal technology, originally developed in Europe and introduced in the U.S. in the late 1960's, has emerged as a preferred method for aseptic packaging of pharmaceutical and healthcare products due to unrivaled flexibility in container design, overall product quality, product output and low operational costs. The Weiler design incorporates the multi-step process of blow molding, asepti...

INTRODUCTION The purpose of this in vitro study was to evaluate the effect of calcium hydroxide, double and triple antibiotic paste on the sealing ability of mineral trioxide aggregate (MTA) apical plugs. METHODS AND MATERIALS A total of 90 extracted teeth with single canals were prepared and randomly divided into four experimental groups (n=20). Intra-canal medicaments were applied for 3 wee...

Key points † Optimizing tracheal sealing is of clinical interest: fluid leakage past the tube cuff plays an important role in the pathogenesis of VAP. † Tapered shaped tube cuff offering a sealing zone with reduced folds and channels is a new strategy to minimize fluid leakage past the tracheal tube cuff. † Tracheal tube cuffs made from PVC show much more and faster fluid leakage than cuffs mad...

Large supraphysiologic transmembrane electrical potentials are known to alter the molecular organization of the bilayer lipid component of cell membranes, leading to ionic permeabilization or "electroporation". Typically, membrane electroporation is followed by several orders of magnitude increases in electrical conductance and diffusive permeability to low-molecular-weight solutes. Electropora...

This study analyzes soil sealing and its repercussions in the loss of fertile soils, which are more appropriate for agriculture use. Also, soil sealing increases flood risk. The main objective is to estimate soil loss by sealing in the Guadarrama River Basin (Madrid, Spain) between 1961 and 2011. The combination of digital processing (Normalized Difference Vegetation Index (NDVI), principal com...

Bone remodeling is dependent on the dynamic equilibrium between osteoclast-mediated bone resorption and osteoblast-mediated osteogenesis. The sealing zone is an osteoclast-specific cytoskeletal structure, the integrity of which is critical for osteoclast-mediated bone resorption. To date, studies have focused mainly on the osteoprotegerin (OPG)‑induced inhibition of osteoclast differentiation t...

BACKGROUND Percutaneous endoscopic lumbar discectomy is a common surgical treatment for lumbar disc herniation, and percutaneous endoscopic interlaminar lumbar discectomy (PEID) is commonly used for direct decompression of L5-S1. Like microdiscectomy, recurrence of herniation after endoscopic discectomy is an important problem. In this study, we aimed to decrease the recurrence after PEID using...