Clathrin-mediated endocytosis (CME) is the major mechanism for internalization in mammalian cells. CME initiates by recruitment of adaptors and clathrin to form clathrin-coated pits (CCPs). Nearly half of nascent CCPs abort, whereas others are stabilized by unknown mechanisms and undergo further maturation before pinching off to form clathrin-coated vesicles (CCVs). Phosphatidylinositol-(4,5)-b...

BACKGROUND CD8+ T cells have been shown to play a crucial role in Trypanosoma cruzi infection. Memory CD8+ T cells can be categorised based on their distinct differentiation stages and functional activities as follows: stem cell memory (TSCM), central memory (TCM), transitional memory (TTM), effector memory (TEM) and terminal effector (TTE) cells. Currently, the immune mechanisms that control T...

This study has critically examined different aspects of Counter-Cyclical Payments (CCPs) in the context of commitment of United State of America (US) under the Agreement on Agriculture (AoA) and future obligations under recent Doha Round Negotiations. The study has highlighted the shortcomings in domestic support notifications of US to WTO and their impact on product-specific support to the agr...

quality control plays an important role in increasing the product quality. fuzzy control charts are more sensitive than shewhart control chart. hence, the correct use of fuzzy control chart leads to producing better-quality products. this area is complex because it involves a large scope of industries, and information is not well organized. in this research, we provide a literature review of th...

Early identification and detection of abnormal time series patterns is vital for a number of manufacturing. Slide shifts and alterations of time series patterns might be indicative of some anomaly in the production process, such as machinery malfunction. Usually due to the continuous flow of data monitoring of manufacturing processes requires automated Control Chart Pattern Recognition (CCPR) a...

VIDEO ABSTRACT Some endocytic cargoes control clathrin-coated pit (CCP) maturation, but it is not known how such regulation is communicated. We found that μ-opioid neuropeptide receptors signal to their enclosing CCPs by ubiquitination. Nonubiquitinated receptors delay CCPs at an intermediate stage of maturation, after clathrin lattice assembly is complete but before membrane scission. Receptor...

In this paper, a learning-based paradigm for scientific chart recognition is proposed. Two kinds of chart recognition methods are presented: hidden Markov model based and neural network based method. A newly developed feature extraction method is also put forward for chart images. Experiments on three kinds of charts show that the ergodic hidden Markov models achieve a satisfactory result for c...