The aim of this study was to investigate the effect of aerial parts of Stachys lavandulifolia Vahl. extract on the rat ileum contractions. The crude extract was prepared by maceration method (90% methanol) followed by fractionating into chloroform, ethyl acetate, petroleum ether and water. In adult male Wistar rats, ileum was sectioned and mounted in tissue bath and their contractility was reco...

Detrusor contractility was measured in the reflex micturition of the decerebrate dog, using a computer directly connected to a urodynamic setup. Detrusor contractility parameters seem to be useful for evaluation of bladder function.

The contribution of the sympathetic innervation to the postnatal development of cardiac contractility remains unclear. In this study, the postnatal maturation of cardiac contractility was compared in control rats and rats after chemical sympathectomy. The chemical sympathectomy was induced by administration of 6-hydroxydopamine to newborn rats. At days 20, 40 and 60 of postnatal life, the contr...

The incidence of heartfailure is increasing every year, while there is no ideaL inotropic agent yet available. Therefore the searchfor an ideaL inotropic agent is still needed. Isoniazid (INH) has been wideLy used as an anti-tuberculosis agent that htts similar structure to the K+ channel blocker 4-aminopyridine. Considering tlnt K* channel blocker may prolong depolarization leading to a more i...

Hypothesis / aims of study Bladder contractility is an important parameter in the diagnosis of lower urinary tract dysfunction. Currently, pressure-flow studies are used to assess bladder contractility by combining flow rate and detrusor pressure into one parameter, e.g. Wmax or WQmax. The determination of Wmax and WQmax is based on a theoretical model (1). Using the non-invasive condom cathete...

BACKGROUND Ureters are fundamental for keeping kidneys free from uropathogenic Escherichia coli (UPEC), but we have shown that 2 strains (J96 and 536) can subvert this role and reduce ureteric contractility. To determine whether this is (1) a widespread feature of UPEC, (2) exhibited only by UPEC, and (3) dependent upon type 1 fimbriae, we analyzed strains representing epidemiologically importa...

The effects of halothane (1.0-1.5%) on myocardial contractility, systemic vascular resistance (representing the majority of impedance to oscillatory flow), and left ventricular performance, and the interactions of these functions have been studied in openchested dogs, artificially ventilated and maintained in a state of basal narcosis with chloralose and urethane. Halothane reversibly depressed...

We investigated the role of K(+) channels in the attenuated pulmonary artery (PA) contractility characteristic of acute Pseudomonas pneumonia. Contractility of PA rings from the lungs of control or pneumonia rats was assessed in vitro by obtaining cumulative concentration-response curves to the contractile agonists KCl, phenylephrine, or PGF(2 alpha) on PA rings before and after treatment with ...