EDITORIAL COMMITTEE: S. NEWCOMB, Mathematics; R. S. WOODWARD, Mechanics; E. C. PICKERING, Astronomy; T. C. MENDENIHALL, Physics; R. H. THURSTON, Engineering; IRA REMSEN, Chemistry; J. LE CONTE, Geology; NW. M. DAVIS, Physiography; 0. C. MARSH, Paleontology; W. K. BROOKS, C. HART MERRIAM, Zoology; S. H. SCUDDER, Entomology; C. E. BESSEY, N. L. BRITTON, Botany; HENRY F. OSBORN, General Biology; C...

EDITORIAL COMMITTEE: S. NEWCOMB, Mathematics; R. S. WOODWARD, Mechanics; E. C. PICKERING, Astronomy; T. C. MENDENHALL, Physics; R. H. THURSTON, Engineering; IRA REMSEN, Chemistry; J. LE CONTE, Geology; W. M. DAVIS, Physiography; HENRY F. OSBORN, Paleontology; W. K. BROOKS, C. HART MERRIAM, Zoology; S. H. SCUDDER, Entomology; C. E. BESSEY, N. L. BRITTON, Botany; C. S. MINOT, Embryology, Histolog...

The trip is not over yet as definite therapy for GNE myopathy is not yet available. Also the exact mechanisms by which GNE defects lead to isolated muscle disease in humans are not fully recognized. But in the Gaetano Conte lecture of 2013 I have tried to describe how much a progress was made in several research laboratories and clinical institutes in the investigation of this unique myopathy.