The authors have designed and produced extended-wear contact lenses for rhesus monkeys. High-plus lenses to correct neonatal aphakia as well as lenses dyed black for use as occluders to treat amblyopia have been evaluated. Four infant monkeys fitted with soft lenses have successfully worn these extended-wear lenses almost continuously throughout their first year of life. These experiments demon...

purpose: to determine the sensitivity and specificity of confocal scan in the diagnosis of fungal and acanthamoeba keratitis based on the results of corneal and/or contact lens case smear and culture. method: confocal scan and corneal and/or contact lens case smear and culture were performed in all patients with a clinical diagnosis of infectious keratitis who were referred to labbafinejad medi...

PURPOSE To examine the rabbit corneal epithelial cell proliferation rate after extended wear of disposable or silicone hydrogel contact lenses or prolonged eyelid closure. METHODS One randomly chosen eye of 40 New Zealand White rabbits was assigned to silicone hydrogel contact lens wear (n = 15, SH), disposable hydrogel contact lens wear (n = 6, DH), eyelid suturing (n = 15, SUT), or no inter...

A study of a syndrome characterised by deficient or inadequate Meibomian gland secretions, minimal or transient symptoms suggestive of ocular dryness, fluorescein staining of the cornea (often detected only after delayed observation or sequential instillation of stain), and contact lens intolerance is described. Clinical and cytological studies indicate that the syndrome is due to obstruction o...

this study compared tear function tests and cytologic changes on the conjunctival surface in asymptomatic patients wearing contact lens of different materials. included in this study were 40 eyes wearing daily wear 4 week replacement hydrogel (h) lenses, 32 eyes wearing silicone hydrogel (sih) lenses, 18 eyes wearing rigid gas-permeable (rgp) lenses, and 21 healthy eyes (no lenses) as the contr...

Corneal thickness changes were monitored in ten subjects (1) over a 36-hour period without contact lens wear and (2) during 7 days continuous wear of three types of hydrogel contact lenses of different back vertex powers. Measured on awakening, the mean overnight central corneal edema without lenses was 3.0% ± 1.2%. With the lenses used in this study, the mean overnight corneal swelling over th...

PURPOSE : To explore the possible mechanisms that may lead to overnight contact lens-associated corneal morbidity by examining data from several corneal epithelial permeability experiments obtained under different environmental and lens fitting paradigms. METHODS : Epithelial permeability was assessed by using fluorometry to determine the fluorescein penetration rate from the tear film into t...

PURPOSE To measure the MRD (margin reflex distance) in rigid contact lens wearers and controls by a new method, based on computerized image processing. METHOD The patients were selected from the Contact Lens Sector of the Ophthalmology Service at the "Complexo Hospitalar Santa Casa de Porto Alegre", and they were divided into two groups: the first was formed of rigid contact lens wearers (63 ...

PURPOSE One strategy to minimize bacteria-associated adverse responses such as microbial keratitis, contact lens-induced acute red eye (CLARE), and contact lens induced peripheral ulcers (CLPUs) that occur with contact lens wear is the development of an antimicrobial or antiadhesive contact lens. Cationic peptides represent a novel approach for the development of antimicrobial lenses. METHODS...