Identifying the binding targets of small molecules is an essential process in drug discovery and development. The two conventional approaches include high throughput screening (HTS) and computational structural docking. HTS suffers from its expensive cost and time-consuming procedure, while the computational methods reply on simplifying assumptions that often leads to less accurate results. In ...

OBJECTIVE The aim of this study was to evaluate (1) the effectiveness of one-step polishers on the surface morphology of enamel using scanning electron microscope (SEM) and compare their effects with conventional systems for residual adhesive removal; and (2) the time spent to remove resin remnants. MATERIAL AND METHODS Metal brackets were bonded to the buccal surface of 80 freshly extracted ...

Failure analysis (FA) and diagnosis of memory cores plays a key role in system-on-chip (SOC) product development and yield ramp-up. Conventional FA based on bitmaps and the experiences of the FA engineer is time consuming and error prone. The increasing time-to-volume pressure on semiconductor products calls for new development flow that enables the product to reach a profitable yield level as ...

Model surgery is the classical requirement for fabricating an intermediate splint for bimaxillary surgery. However, several sources of error complicate the conventional manual technique for making an intermediate splint, and it can be difficult to reposition the cast model of the upper jaw in the desired position. Additionally, the manual procedure is time consuming and requires a lot of labora...

In 22nm optical lithography and beyond, source mask optimization (SMO) becomes vital for the continuation of advanced ArF technology node development. The pixel-based method permits a large solution space, but involves a time-consuming optimization procedure because of the large number of pixel variables. In this paper, we introduce the Zernike polynomials as basis functions to represent the so...

Biologically active proteins are useful for studying the biological functions of genes and for the development of therapeutic drugs and biomaterials in a biotechnology industry. Overexpression of recombinant proteins in bacteria, such as Escherichia coli, often results in the formation of inclusion bodies, which are protein aggregates with non-native conformations. As inclusion bodies contain r...

With the advent of the cDNA microarray and oligonucleotide array technologies it has become possible to study a large number of genes in a single experiment. While experiments with thousands of genes are routinely performed, searching for literature about several genes by traditional methods is time consuming and error-prone. In addition to the inherent limitations of free text search, use of t...

Semiquantitative and rapid detection of specific IgE (sIgE) with well clinical relevance to house dust mite (HDM) are promising for prevalence rhinitis and asthma patients due to the increasing air pollution. However, the conventional IgE measurement systems are time-consuming, complicated and require special instruments. Herein, we overcome the above limitations of sIgE to HDM detection system...

Chrysotile is one of the asbestos types minerals and it fibrous form in nature. Also, chrysotile may cause health problems. Accordingly, better to be known whether exists a construction site advance so that constructor can take counter plan for worker health. However, identifying small amount very difficult. In conventional way, experts quantify by using microscope X-ray diffraction analysis. I...

the strength of concrete is a function of the proportions of the constituent materials, namely, cement, water, fine and coarse aggregates. the conventional methods used to determine the mix proportions that will yield the desired strength, are laborious, time consuming and expensive. in this paper, a mathematical method based on modified regression theory is formulated for the prediction of con...