Constipation is a frequently overlooked side effect of clozapine treatment that can prove fatal. We conducted a systematic review and meta-analysis to estimate the prevalence and risk factors for clozapine-associated constipation. Two authors performed a systematic search of major electronic databases from January 1990 to March 2016 for articles reporting the prevalence of constipation in adult...

The term constipation refers to a symptom or complex of symptoms and not a specific diagnosis. Patients and health care providers often define constipation differently. Most health care providers define constipation based on stool frequency. Patients often use the term constipation to describe a broad set of complaints, including straining, hard or infrequent stools, pain during a bowel movemen...

PURPOSE This study was designed to evaluate the risk on development and persistence of constipation after hysterectomy. METHODS We conducted a prospective, observational, multicenter study with three-year follow-up in 13 teaching and nonteaching hospitals in The Netherlands. A total of 413 females who underwent hysterectomy for benign disease other than symptomatic uterine prolapse were inclu...

BACKGROUND Celiac disease is a glutten induced enteropathy. Some authors recommended screening celiac in children with constipation. There are studies to evaluate celiac disease in children with constipation. But most of them included children regardless to treatment failure. OBJECTIVE The aim of this study was to evaluate frequency of elevated anti TTG in children with constipation after fai...

Background. Comorbidity in chronic constipation has rarely been investigated, despite the fact that constipation can occur as one symptom in a number of neurological, systemic, and other nonintestinal and intestinal disorders. Methods. Of 1037 individuals with constipation identified during a telephone survey, 589 returned a postal questionnaire with valid data, asking for sociographic data, cl...

BACKGROUND We aimed to review the literature regarding the epidemiology of constipation in Europe and Oceania and the associated prevalence/risk factors. METHODS Two reviewers performed PubMed searches and a hand search of references. A study was considered eligible for inclusion if it reported data about the prevalence of constipation in any population, free of other gastrointestinal disorde...

Constipation is a common complaint in older adults. Although constipation is not a physiologic consequence of normal aging, decreased mobility and other comorbid medical conditions may contribute to its increased prevalence in older adults. Functional constipation is diagnosed when no secondary causes can be identified, such as a medical condition or a medicine with a side effect profile that i...