Identifying hot-spot residues - residues that are critical to protein-protein binding - can help to elucidate a protein's function and assist in designing therapeutic molecules to target those residues. We present a novel computational tool, termed spatial-interaction-map (SIM), to predict the hot-spot residues of an evolutionarily conserved protein-protein interaction from the structure of an ...

Single molecule surface enhanced Raman scattering (SM-SERS) is a highly local effect occurring at sharp edges, interparticle junctions and crevices or other geometries with a sharp nanoroughness of plasmonic nanostructures ("hot spots"). The emission of an individual molecule at SM-SERS conditions depends on the local enhancement field of the hot spots, as well as the binding affinity and posit...

We report the first detection of CO emission at high spectral resolution in day-side infrared thermal spectrum an exoplanet. These lines, found atmosphere transiting ultra hot Jupiter (UHJ) WASP-33 b, provide unambiguous evidence its inversion. Using spectra from MMT Exoplanet Atmosphere Survey (MEASURE, $R\sim15,000$), covering pre- and post-eclipse phases, we cross-correlate with 1D PHOENIX t...

Sagittarius A*, the supermassive compact object at the center of the Galaxy, exhibits outbursts in the near infrared and X-ray domains. These flares are likely due to energetic events very close to the central object, on a scale of a few Schwarzschild radii. Optical interferometry will soon be able to provide astrometry with an accuracy of this order (≃ 10 μas). In this article we use recent ph...

Most excellent object-oriented frameworks are still the product of a more or less chaotic development process, typically carried out in the realm of research-like settings. Overall, flexibility has to be injected into a framework in appropriate doses1. Framework adaptation takes place at points of predefined refinement that we call hot spots. As the quality of a framework depends directly on th...

In this research and development project we are exploring a new approach of mobile web and location-based services (LBS) for communication / collaboration which is based on a physical hot spot serving as an accumulation point; a hub for thematic and social collaboration. Different actors can consult, publish or exchange information in relation with the location materialized by the hot spot. Thi...

The main function of a wireless sensor network is to sense the outside environment and report the data to a processing center. Therefore, both sensing and communication roles should be considered for a sensor network. Except for the mobility aspect, sensor networks inherit almost all properties of ad hoc networks. Therefore, sensor nodes are supposed to report data to a common sink instead of s...

A recent report from the Milagro collaboration included an all-sky map created using one year of data from Milagro (peak sensitivity at 3-4 TeV for Crab-like spectra). This map included an unidentified excess that was brighter than the Crab and was the second brightest spot on the map. The hot spot was within the error box of the EGRET unidentified source 3EG J0520+2556. No strong and steady em...