Meningitis developed in 3 of 14 children with occult pneumococcaemia; in 2 of them it developed while they were being treated with low doses of intravenous penicillin, in the third child it developed at a time when he was not being treated. All children with occult pneumococcaemia should be treated with intravenous penicillin as are those with pneumococcal meningitis.

Auxin is a plant hormone involved in an extraordinarily broad variety of biological mechanisms. These range from basic cellular processes, such as endocytosis, cell polarity, and cell cycle control over localized responses such as cell elongation and differential growth, to macroscopic phenomena such as embryogenesis, tissue patterning, and de novo formation of organs. Even though the history o...

IMPORTANCE The death of a loved one is one of life's greatest, universal stressors to which most bereaved individuals successfully adapt without clinical intervention. For a minority of bereaved individuals, grief is complicated by superimposed problems and healing does not occur. The resulting syndrome of complicated grief causes substantial distress and functional impairment even years after ...

Lymphangioleiomyomatosis, a multisystem disease characterized by cystic lung lesions can result in respiratory failure and is considered to be sex hormones related. No effective treatment for lymphangioleiomyomatosis is currently available. We report a 35-year-old patient in her second pregnancy. She also had experienced five episodes of spontaneous pneumothorax at the age of 30. Despite excess...

RATIONALE Pregnancy is a complicated physiological process. Physiological leukocytosis often takes place and it is primarily related to the increased circulation of neutrophils, especially during the last trimester of pregnancy. Noncongenital agranulocytosis during pregnancy is rare and reported only occasionally, while in most of the cases, the agranulocytosis has already occurred prior to pre...

Background and Importance: Arachnoid cysts are benign nontumoral lesions that are usually found incidentally in brain imaging. Suprasellar Arachnoid Cysts (SSACs) are rare. They can cause hydrocephalus and increased intracranial pressure, lower cranial nerve impairment and endocrine disorder. Sometimes arachnoid cysts become complicated by subdural hematoma/hygroma.  Case Presentation: We...

has coordinated a terrifi c issue of Pediatric Annals, with a group of outstanding articles devoted to the child with complex medical needs. The fi rst four articles in the issue deal with the scien-tifi c and medical aspects of providing care to this patient population. Julie Hauer (see page 198) systematically clarifi es the mechanisms that cause pain in neurologi-cally impaired children, hig...