BACKGROUND The 5% Lidocaine patch is used for treating chronic neuropathic pain conditions such as chronic back pain (CBP), diabetic neuropathy and complex regional pain syndrome, but is effective in a variable proportion of patients. Our lab has reported that this treatment reduces CBP intensity and associated brain activations when tested in an open labelled preliminary study. Notably, effect...

CREST plays a critical role in activity-dependent development, but its mechanism of action is not well understood. Here, we show that a CREST-BRG1 complex regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-fos promoter is inhibited by BRG1-dependent recruitment of...

The aging of IMR-90 human diploid fibroblasts in culture is accompanied by a 5-7 fold decrease in the level of thymidine kinase (TK) mRNA and TK activity (Chang, Z. F., and Chen, K. Y. (1988) J. Biol. Chem. 263, 11431-11435). We have employed a gel mobility shift analysis to investigate the molecular basis of the age-dependent attenuation of TK gene expression. Several cis-elements including tw...

In developmental biology, the regulation of stem cell plasticity and differentiation remains an open question. CBP(CREB-binding protein)/p300 is a conserved gene family that functions as transcriptional co-activator plays important roles in wide range cellular processes, including death, DNA damage response, tumorigenesis. The acetyl transferase activity CBPs particularly important, histone non...

We have simulated the interferometric observation of the Cosmic Microwave Background (CMB) temperature and polarization fluctuations. We have constructed data pipelines from the time-ordered raw visibility samples to the CMB power spectra which utilize the methods of data compression, maximum likelihood analysis, and optimal subspace filtering. They are customized for three observational strate...

Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise, to republish, to post on servers or to redistribute to lists, requires prior specific permission....

Overexpression of the CREB-binding protein (CBP), a bromodomain-containing transcription coactivator involved in a variety of cellular processes, has been observed in several types of cancer with a correlation to aggressiveness. We have screened a library of nearly 1500 fragments by high-throughput docking into the CBP bromodomain followed by binding energy evaluation using a force field with e...

The paper proposes fourth order Butterworth complex filter for the Global Positioning System (GPS) receiver, which the center frequency of complex filter is 2MHz and bandwidth is 2 MHz. The operational amplifier (OPA) is designed as twostage fully differential OPA. The gain bandwidth (GBW) of operation amplifier reaches 300MHz, the gain of the DC is 58.3dB, the phase margin is 5 7  and the pow...