Activation of the alternative pathway of complement is implicated in common neurodegenerative diseases including age-related macular degeneration (AMD). We explored the impact of common variation in genes encoding proteins of the alternative pathway on complement activation in human blood and in AMD. Genetic variation across the genes encoding complement factor H (CFH), factor B (CFB) and compo...

Serum complement opsonizes particles such as bacteria for clearance by the reticuloendothelial system. Complement has been reported to interact with liposomes and therefore may mediate the reticuloendothelial system clearance of liposomes. This study has used a rat serum model to define some of the characteristics of liposomes which modulate their ability to activate complement. Using functiona...

Several complement proteins interact with hemostatic factors. We discovered that von Willebrand factor (VWF) acts as a cofactor for factor I-mediated cleavage of complement C3b, thereby shutting down complement activation. The complement regulatory function of VWF multimers depends on their size. Smaller VWF multimers enhance cleavage of C3b but large and ultra-large VWF (ULVWF) multimers have ...

background: the serum levels of c 3 , c4, and the total hemolytic activity of complement system (ch50) of patients ex­posed to mustard gas (mg) in the battlefield were measured in this study. methods: c3 and c4 were measured by single radial immunodifusion and ch50 was evaluated according to total hemolytic activ­ity of the serum. results:   the serum levels of c 3 showed a significant increase...

Extracellular signals may be transmitted to nuclear or cytoplasmic effectors via the mitogen-activated protein kinases. In the passive Heymann nephritis (PHN) model of membranous nephropathy, complement C5b-9 induces glomerular epithelial cell (GEC) injury, proteinuria, and activation of phospholipases and protein kinases. This study addresses the complement-mediated activation of the extracell...

• ART possesses anti-complement bioactivities. is involved in three effector pathways of complement interception. targets C1q likely via binding globular head region. specifically binds to the key therapeutic C1q, C3 and C5. A modified ELISA selectively allows activation. Complement an important innate immune defence machinery. Once dysregulated, it often linked pathogenesis diverse autoimmune ...

Congenital and acquired deficiencies of complement regulatory proteins are associated with pathologic complement activation in several renal diseases. To elucidate the mechanisms by which renal tubular epithelial cells (TECs) control the complement system, we examined the expression of complement regulatory proteins by the cells. We found that Crry is the only membrane-bound complement regulato...

background and objectives: complement proteins are some of the most important plasma proteins of the innate immune system. impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. this study was conducted to show whether serum c3 and c4 complement change in adult nonpregnant female with iron deficient anemia or ...