The exploration of new alloys with desirable properties has been a long-standing challenge in materials science because of the complex relationship between composition and microstructure. In this Research Article, we demonstrate a combinatorial strategy for the exploration of composition dependence of microstructure. This strategy is comprised of alloy library synthesis followed by high-through...

Non-biological synthetic oligomers can serve as ligands for antibodies. We hypothesized that a random combinatorial library of synthetic poly-N-substituted glycine oligomers, or peptoids, could represent a random "shape library" in antigen space, and that some of these peptoids would be recognized by the antigen-binding pocket of disease-specific antibodies. We synthesized and screened a one be...

During the past decade, combinatorial chemistry has become an integral component of nearly all drug discovery efforts (1-4). Mass spectrometry (MS) has played a key role in the advancement of combinatorial chemistry efforts: in reaction monitoring and optimization of library synthesis, in the purification of libraries synthesized in a parallel format, and in the assessment of library compound q...

The fast pace of drug discovery programs, aided by highthroughput screening campaigns, often relies on the generation of combinatorial libraries to identify new chemical entities. The Ugi 4and 3-component reactions in particular [1], have proven to be robust in producing both tool compounds and drugs [2,3]. Here we report a high-throughput entry into the imidazopyridine scaffold, using a microf...

Cadmium promoted diastereoselective amplification of a single member from a dynamic combinatorial library of stereoisomeric oligoimines of different sizes allows the efficient preparation of a new macrocyclic polyamine.

N-acetyl glucosamine binding protein amplifies the concentration of one member in a dynamic combinatorial glycopeptide library based on exchanging disulfides.

Early results from screening combinatorial libraries have been disappointing with libraries either failing to deliver the improved hit rates that were expected or resulting in hits with characteristics that make them undesirable as lead compounds. Consequently, the focus in library design has shifted toward designing libraries that are optimized on multiple properties simultaneously, for exampl...

We have designed small focused combinatorial library of hexapeptide inhibitors of NS3 serine protease of the hepatitis C virus (HCV) by structure-based molecular design complemented by combinatorial optimisation of the individual residues. Rational residue substitutions were guided by the structure and properties of the binding pockets of the enzyme's active site. The inhibitors were derived fr...

Screening a diverse, combinatorial library of ca. 5000 synthetic dimer and trimer N-(substituted)glycine "peptides" yielded novel, high-affinity ligands for 7-transmembrane G-protein-coupled receptors. The peptoid library was efficiently assembled using readily available chemical building blocks. The choice of side chains was biased to resemble known ligands to 7-transmembrane G-protein-coupled...

Phage-encoded peptide libraries are often used to study biomolecular interactions. We employed this combinatorial approach to identify ligands specific for the streptococcal collagen-like proteins, Scl1 and Scl2, which are expressed on the cell surface by group A Streptococcus. Several sequence motifs displayed by phages were selected for their binding ability to different Scl variants. D 2005 ...