Since the original description of colonic varices in 1954 [N Engl J Med 1954;250:434-438], fewer than 100 cases have been reported in the literature. Particularly, even fewer cases of cecal varices have been reported. More than 75% of these cases have been due to portal hypertension. Our objective is to contribute a rare case with an uncommon presentation to the medical literature. We present t...

The myofibroblast is an important stromal cell of the gastrointestinal tract. Current in vitro and in vivo models either do not accurately recreate stromal-epithelial interactions or are not specific to myofibroblasts. We sought to create an animal model that would allow the study of myofibroblast-epithelial interactions. We isolated and cultured colonic myofibroblasts from FVB mice. Cells were...

introduction: functional constipation is one of the most common gastrointestinal symptoms which could affect patients’ quality of life. the colonic transit time test could be used for determining functional constipation subtypes. the aim of our study was to determine the abnormalities of the subtypes of functional constipation using ctt. methods and materials: this cross-sectional study was per...

objective(s):the aim of this study was to prepare electrospun nanofibers of celecoxib using combination of time-dependent polymers with pectin to achieve a colon-specific drug delivery system for celecoxib. materials and methods:formulations were produced based on two multilevel 22 full factorial designs. the independent variables were the ratio of drug:time-dependent polymer (x1) and the amoun...

c 2017 The Korean Society of Neurogastroenterology and Motility J Neurogastroenterol Motil, Vol. 23 No. 4 October, 2017 www.jnmjournal.org TO THE EDITOR: Acute colonic pseudo-obstruction (ACPO, also called Ogilvie’s syndrome) is a rare disorder characterized by colonic dilatation in the absence of a mechanical cause. Although ACPO is an important cause of morbidity and mortality, the pathophysi...

background: complete colonic duplication is a very rare congenital anomaly that may have different presentations according to its location and size. complete colonic duplication can occur in 15% of gastrointestinal duplication. we report two cases of complete colonic duplications, and their characteristics. case presentation: we present two patients with complete colonic duplication with differ...

BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by peripheral antigen which homed to the colonic mucosa. The clonal distribution of I...

Halm ST, Zhang J, Halm DR. -Adrenergic activation of electrogenic K and Cl secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways. Am J Physiol Gastrointest Liver Physiol 299: G81–G95, 2010. First published April 22, 2010; doi:10.1152/ajpgi.00035.2010.—Adrenergic stimulation of isolated guinea pig distal colonic mucosa produced transient Cl and sustained...

Sahi, Jasminder, Selvaraj G. Nataraja, Thomas J. Layden, Jay L. Goldstein, M. P. Moyer, and Mrinalini C. Rao. Cl2 transport in an immortalized human epithelial cell line (NCM460) derived from the normal transverse colon. Am. J. Physiol. 275 (Cell Physiol. 44): C1048–C1057, 1998.—Cells of a newly described, immortalized, epithelial, human transverse colonic cell line, NCM460, reach ,90% confluen...

Outwardly rectifying 30-50-pS Cl- channels mediate cell volume regulation and transepithelial transport. Several recent reports indicate that rectifying Cl- channels are blocked after addition of ATP to the extracellular bath (Alton, E. W. F. W., S. D. Manning, P. J. Schlatter, D. M. Geddes, and A. J. Williams. 1991. Journal of Physiology. 443:137-159; Paulmichl, M., Y. Li, K. Wickman, M. Acker...