Most studies of the impacts of sea level rise (SLR) have explored scenarios of ,1 m during the 21st century, even though larger rises are possible. This paper takes a different approach and explores and quantifies the likely flood impacts in the Thames estuary for a number of plausible, but unlikely, SLR scenarios. The collapse of the Western Antarctic Ice Sheet (WAIS) could cause global mean s...

the circulatory blood volume (oligaemia) is the most important factor in the production of wound shock, and that circulatory collapse occurs if a patient's effective blood volume is reduced below 70 per cent of normal. Grant and Reeve conclude that the most valuable signs in determining the degree of reduction in blood volume are the amount of tissue damage, and the systolic blood pressure. The...

This study aims at better understanding the damage tolerance of stiffened composite panels subjected to fatigue loads in post-buckling regime. Ten single-stringer hat-stiffened specimens with an initial delamination between skin and stringer foot were manufactured, then tested under quasi-static conditions, different load levels ratios. The tests monitored digital image correlation ultrasonic s...

6- mercaptopurine (6-mp) is widely used in clinic as an immunosuppressive for treatment of acute lymphocytic leukemia, crohn's disease, and ulcerative colitis with documented unpredictable hepatotoxicity. the potential molecular cytotoxic mechanisms of 6-mp against isolated rat hepatocytes were searched in this study using “accelerated cytotoxicity mechanism screening (acms)” techniques. t...

chloroacetaldehyde (caa) is a chlorination by-product in finished drinking water and a toxic metabolite of a wide variety of industrial chemicals (e.g. vinyl chloride) and chemotherapeutic agents (e.g. cyclophosphamide and ifosfamide). in this research, the cytotoxic mechanisms of caa in freshly isolated rat hepatocytes were investigated.caa cytotoxicity was associated with reactive oxygen spec...

Massive stars in their final stages of collapse radiate most of their binding energy in the form of MeV neutrinos. The recoil atoms that they produce in elastic scattering off nuclei in organic tissue create radiation damage which is highly effective in the production of irreparable DNA harm, leading to cellular mutation, neoplasia, and oncogenesis. Using a conventional model of the galaxy and...

Using large system sizes with extensive statistical sampling, we analyze the scaling properties of crack roughness and damage profiles in the three-dimensional random fuse model. The analysis of damage profiles indicates that damage accumulates in a diffusive manner up to the peak load, and localization sets in abruptly at the peak load, starting from a uniform damage landscape. The global crac...

Members of a panel of stress-responsive biosensors have been used to study the effect of megahertz frequency ultrasound on Escherichia coli. Insonification causes acoustic cavitation, the collapse of oscillating microbubbles in solution, which can damage bacterial cells. A focused 1-MHz ultrasound transducer, capable of generating a spatial peak pulse average intensity of 500 W/cm2, was used to...

Structural alterations in DNA can serve as natural impediments to replication fork stability and progression, resulting in DNA damage and genomic instability. Naturally occurring polypurine mirror repeat sequences in the human genome can create endogenous triplex structures evoking a robust DNA damage response. Failures to recognize or adequately process these genomic lesions can result in loss...

Mounier Kuhn syndrome, or congenital tracheobronchomegaly, is an under diagnosed clinical entity with peculiar anatomical and physiological features making anesthetic care challenging. A 58-year-old chronic smoker with history of recurrent pneumonia and bronchiectasis presented for septoplasty. Thoracic imaging revealed a dilated trachea and main bronchi, tracheal and bronchial diverticuli, and...