Spirulina platensis, a filamentous, multicellular microalga, is grown in certain countries as food for human and animal consumption. It is also used to derive additives in pharmaceuticals and foods. The present study was undertaken to examine the immunomodulatory effect of S. platensis in collagen induced arthritis (CIA) in rats. From the zero day of induction of arthritis, S. platensis (200 an...

Collagen-induced arthritis in the DBA/1 mouse is an experimental model of human rheumatoid arthritis. To examine the role of leukotrienes in the pathogenesis of this disease, we have developed embryonic stem (ES) cells from this mouse strain. Here, we report that DBA/1 mice made deficient in 5-lipoxygenase-activating protein (FLAP) by gene targeting in ES cells develop and grow normally. Zymosa...

Abstract TARM1 is a member of the leukocyte immunoglobulin-like receptor family and stimulates macrophages neutrophils in vitro by associating with FcR?. However, function this molecule regulation immune system unclear. Here, we show that Tarm1 expression elevated joints rheumatoid arthritis mouse models, development collagen-induced (CIA) suppressed –/– mice. T cell priming against type 2 coll...

Administration of intravenous immunoglobulin (IVIg) is a recognized safe and efficient immunomodulation therapy for many autoimmune diseases. Anti-idiotypic antibody binding to pathogenic autoantibodies was proposed as one of the mechanisms attributed to the protective activity of IVIg in autoimmunity. The aim of this study was to fractionate the anti-anti-citrullinated protein anti-idiotypic-a...

Amongst extraintestinal manifestations (EIM) occurring in IBD patients, rheumatologic manifestations are the most frequent. Understanding the relationships between arthritis and colitis is a prerequisite to improving the management of these patients. Microbiota of patients with IBD or rheumatologic diseases, like spondyloarthritis (SpA) is modified compared to healthy individual. Thus, we have ...

about our recent study [2] and would like to make two points to clarify our reasoning. First, in our study [2], female Lewis rats have been used in order to induce arthritis. Th is experimental model of arthritis was well described in our previous study published in Molecular Th erapy [3]. Actually, a number of researchers use male or female animals to induce arthritis. For example, the use of ...

BACKGROUND Apoptotic cell-based therapies have been proposed to treat chronic inflammatory diseases. The aim of this study was to investigate the effect of intravenous (i.v.) apoptotic cell infusion in ongoing collagen-induced arthritis (CIA) and the interaction of this therapy with other treatments used in rheumatoid arthritis (RA), including methotrexate (MTX) or anti-TNF therapy. METHODS T...

This study was undertaken to develop a novel anti-citrullinated peptide antibody (ACPA) and to investigate its arthritogenicity in a collagen-induced arthritis (CIA) model. The novel ACPA, 12G1, was developed by injecting cyclic citrullinated antigen in mice and subsequently hybridizing the B cells producing citrullinated peptide-specific antibodies with a myeloma cell line. The arthritic joint...

OBJECTIVE To examine the effect of LY309887, an inhibitor of glycinamide ribonucleotide formyltransferase in de novo purine biosynthesis on murine type collagen-induced arthritis (CIA). METHODS CIA was induced by immunization with bovine type II collagen in adjuvant. The expression of folate receptors was examined in dissected synovial tissues and bone marrow cells from arthritic and non-arth...