TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: Cold agglutinin disease (CAD) is classified into primary or secondary type that associated with malignancy. agglutinins are antibodies specific for erythrocyte surface antigens. This antigen-antibody complex gets activated when blood flows through the periphery, leading to complement activation and hepatic sequestrat...

Cold agglutinin disease (CAgD) is a type of autoimmune hemolytic anemia which generally occurs in adults and is characterized by the presence of IgM antibodies directed against polysaccharide antigens on red blood cell surface. A 16-year-old male, having clinical picture of sepsis and anemia, presented to the Emergency Department of our Institute in an Hemodynamically unstable condition. Invest...

A 72-year-old woman presented to the emergency room with acute onset adynamia and tachycardia. On physical examination, icterus and splenomegalia were noted. The first blood specimens could not be analyzed because of the rapid clotting of all samples in the blood tubes at room temperature. After placing drawn blood samples in a warm water bath, clotting occurred in the upper part of the tube no...

In most cases, immune-mediated hemolysis occurs extravascularly and is associated with IgG antibodies on the surface of red cells. Rare syndromes include IgG antibodies that cause direct intravascular hemolysis, such as paroxysmal cold hemoglobinuria. Also rare are extravascular hemolytic syndromes caused by IgM polyclonal or monoclonal antibodies that demonstrate red cell agglutination at 3 de...

Severe cold agglutinin disease with hemodynamic compromise requires rapid stabilization of the autoimmune hemolytic anemia as a bridge to the immunosuppressive effect of rituximab. Herein, we describe eculizumab treatment of severe complement-mediated hemolysis in a patient whose hemodynamic status deteriorated in spite of supportive blood transfusions and therapeutic plasma exchange.

Background: Malarial infection associated with common hematological abnormalities like anemia, Thrombocytopenia, Hemolytic anemia. Hemolytic anemia is due to occurrence of cold agglutinins. This study throws light on the prevalence of cold agglutinins in patients with malarial infection and their detection. Method: About 150 patients diagnosed as having Malaria by Peripheral smear, QBC for mala...