Coenzyme Q10 is a vitamin-like substance used in the treatment of a variety of disorders primarily related to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of coenzyme Q10 appear most promising for neurodegenerative disorders such as Parkinson's disease and certain encephalomyopathies for which coenzyme Q10 has gained orphan drug status. Results in ...

It was reported previously that coenzyme A contained pantothenic acid bound in such a manner as to make it unavailable in microbiological tests (1). A liberation of p;alanine on acid hydrolysis indicated early the presence of pantothenic acid, which was confirmed by chick assay (2). While the chick assay for pantothenic acid and the p-alanine assay by the yeast growth test yielded equivalent am...

The absorption spectra of the 5,6-dimethylbenaimidazolylcobamide coenzyme (coenzyme Blz) and its benzimidaeolecontaining analogue (benzimidazolylcobamide coenzyme) are different from that of the adenine-containing analogue (adeninylcobamide’ coenzyme (1, 2)). The most conspicuous difference is in the wave length of the absorbancy maximum in the visible region. The spectra of the two benzimidazo...

OBJECTIVE The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes. METHOD This case-control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylat...

Aerobacter aerogenes converts propanediol to propionaldehyde, and ethylene glycol to acetaldehyde.' Dioldehydrase, the enzyme that catalyzes this reaction, has been purified 200-fold and a requirement for any one of three cobamide coenzymes and for a monovalent metal ion has been established.2 The present work seeks to extend the limited information3 now available on the mechanism of action of ...

Cardiolipin is a major mitochondrial membrane glycerophospholipid in the mammalian heart. In this study, the ability of the isolated intact rat heart to remodel cardiolipin and the mitochondrial enzyme activities that reacylate monolysocardiolipin to cardiolipin in vitro were characterized. Adult rat heart cardiolipin was found to contain primarily linoleic and oleic acids. Perfusion of the iso...

The formation of tryptophan (Reactions 1 and 2) requires the coenzyme pyridoxal phosphate. According to the proposed mechanism of action of pyridoxal enzymes (3, 4), the aldolyticl activity of tryptophan synthetase (Reactions 3f and 3r) would not be expected to require pyridoxal-P as a coenzyme; yet DeMoss and Bonner (7) reported that the Reaction 3f activity of a mutationally altered tryptopha...

Since 5, 6-dimethylbenzimidazolyl cobamide coenzyme (coenzyme B12) as one of the coenzyme forms of vitamin B12 was reported by Barker et al. (1) for the first time in 1960, a good deal of works have been carried out on its biochemical and physiological roles (2-8). The recent knowledge concerning the coenzyme has revealed that it is an active form of vitamin B12 (5, 6-dimethylbenzimidazolyl cob...

OBJECTIVE To evaluate the effectiveness of coenzyme Q(10) treatment in improving semen quality in men with idiopathic infertility. DESIGN Placebo-controlled, double-blind randomized trial. SETTING Andrology Unit, Department of Internal Medicine, Polytechnic University of Marche, Italy. PATIENT(S) Sixty infertile patients (27-39 years of age) with the following baseline sperm selection cri...