نتایج جستجو برای: codon 72 polymorphism
تعداد نتایج: 213974 فیلتر نتایج به سال:
A. Storey et al. [Nature (Lond.), 393: 229-234, 1998)] reported a 7-fold increased risk of cervical cancer associated with having an Arg/Arg polymorphism at codon 72 of p53 compared with the Pro/Arg heterozygotes (odds ratio, 7.4; 95% confidence interval, 2.1-29.4). Complementary in vitro studies suggested that the HPV E6 oncoprotein more readily targets the arginine form, as opposed to the pro...
BACKGROUND Deletion or functional loss of the p53 tumor suppression gene plays a role in oncogenic transformation. The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), and is associated with an increased susceptibility of cancers of the lung, esophagus, breast, cervix and nasopharynx on a genetic basis. We designed this study...
background: systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. the importance of some genes in the development of systemic lupus erythematosus has been implicated. the gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has b...
The objective of this study was to assess the effects of an upstream estrogen response element (ERE) on exogenous p53 tumor suppressor gene with a codon 72 polymorphism about which there have been controversial reports in relation to cancer risk. The p53 gene (bases 166-1143 from start codon) with the codon 72 polymorphism, inserted into the pIRES-hrGFP II plasmid with or without upstream ERE, ...
Background: p53 codon 72 polymorphism is associated with esophageal cancer (EC). Human papillomavirus (HPV) infection is considered as a risk factor of EC. However, the association of p53 codon 72 polymorphism with the risk of HPV-related EC remains inconsistent. Hence, we aimed to investigate the association between p53 codon 72 polymorphism and HPV-related EC risk through meta-analysis. Metho...
the tp53 tumor suppressor gene plays important roles in genomic stability. a common polymorphism at codon 72 of tp53 gene has been associated with increased risk for many human cancers. the p53 protein is expressed in colorectal cancer, but the reported prevalence of its expression varies widely. in the present study, the p53 protein expression in different genotypes of its codon 72 , was inves...
Several lines of evidence are implicating an increased persistence of apoptotic cells in patients with asthma. This is largely due to a combination of inhibition, or defects in the apoptotic process and/or impaired apoptotic cell removal mechanisms. Among apoptosis-inducing genes, an important role is played by p53. In the present study, we have investigated the possible relationship between p5...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید