Cobra venoms contain heat stable, basic, proteins that inhibit iodide accumulation by thyroid slices. Activity is not related to the content of phospholipase A or various other enzymatic activities. These proteins are present only in Elapid venoms and not in snakes of the Crotalidae or Viperidae families. Two such basic proteins, named cobramines A and B, have been purified from the crude venom...

Acute experimental pyelonephritis has been produced by a combination of mechanical ureteral obstruction and intravenous injection of E. coli (strain IMRU-54). The effects of administration of cobra venom factor, an inhibitor of the complement system, on the sequence of morphologic events in the kidneys have been studied by light and electron microscopy.Pronounced bacterial colonization and supp...

Recent investigations have indicated an association between the coagulation and complement systems. Our present studies, designed to explore this association further, demonstrated that a purified anticomplementary fraction of cobra venom, cobra venom factor (CVF), produced significant changes in hemostasis when injected into guinea pigs. Some of the effects described may be secondary to the tra...

Cobra venoms contain heat stable, basic, proteins that inhibit iodide accumulation by thyroid slices. Activity is not related to the content of phospholipase A or various other enzymatic activities. These proteins are present only in Elapid venoms and not in snakes of the Crotalidae or Viperidae families. Two such basic proteins, named cobramines A and B, have been purified from the crude venom...

Recent investigations have indicated an association between the coagulation and complement systems. Our present studies, designed to explore this association further, demonstrated that a purified anticomplementary fraction of cobra venom, cobra venom factor (CVF), produced significant changes in hemostasis when injected into guinea pigs. Some of the effects described may be secondary to the tra...

The complement system is an intrinsic part of the immune system and has important functions in both innate and adaptive immunity. On the other hand, inadvertent or misdirected complement activation is also involved in the pathogenesis of many diseases, contributing solely or significantly to tissue injury and disease development. Multiple approaches to develop pharmacological agents to inhibit ...

Snake venom ophthalmia is an acute reaction of the ocular surface tissues to venom ejected into the eyes of spitting cobra victims. The condition is uncommon and the victim may be frightful of going blind. However permanent vision loss is rare. This case (40-year-old man) is reported to discuss the management protocol in such cases. Immediate copious irrigation of the eye is the most important ...

Snake venoms are known to cause different metabolic disorders, altering cellular and enzymatic activities in animals and releasing pharmacological substances. The objective of this study is to explore the effect of the lethal dose of Indian cobra (Naja naja) venom snake on the lung tissue of albino rats. The rats were divided into three groups, the first group served as a control group, while t...

OBJECTIVE To look into the feasibility of using cobra snake venom in suppressing breast cancer tissue through inhibition of nucleic acid synthesis. METHODS Samples of breast cancerous tissue, obtained from Atomic Energy Medical Center, LMCH, Jamshoro, incubated with varying concentrations of venom and without venom (as controls) were assayed for macromolecular (RNA and DNA) levels RESULTS N...

Venomous snakebites are an important health problem in tropical and subtropical countries. King cobra (Ophiophagus hannah) is the largest venomous snake found in South and Southeast Asia. In this study, the O. hannah venom proteome and the venom components cross-reactive to N. kaouthia monospecific antivenin were studied. O. hannah venom consisted of 14 different protein families, including thr...