Venous thromboembolism (VTE) is major health problem and is sometimes complicated by lethal pulmonary embolism (PE). Disturbances of the coagulation and anticoagulation systems are important risk factors for VTE. Comparative studies suggest that coagulation and innate immunity have a shared evolutionary origin. It is therefore unsurprising that the immune and coagulation systems are linked, wit...

Venous thromboembolism (VTE) in children is an important clinical concern for which risk factors include clinical conditions that incite venous stasis, endothelial damage, or thrombophilia (i.e., hypercoagulability) states. Acquired thrombophilia and markers of coagulation activation are common in pediatric VTE, while potent genetic thrombophilia states are less frequently encountered; neverthe...

background & aim: evaluation of prevalence of risk factors for breast cancer in different regions of iran and identification of their significant effect on this disease can promote the prevention and reduction of breast cancer incidence. therefore, this study aimed to evaluate the prevalence, demographic characteristics, and frequency of the risk factors of breast cancer during 10 years. method...

conclusions sphingomonas paucimobilis can cause serious infections, especially in immunocompromised patients with determined risk factors such as indwelling catheters and diabetes mellitus, due to the effects of multiple virulence factors, together with biofilm formation. results all the clinical isolates of s. paucimobilis produced biofilms. primary bacteraemia (n = 16) was the most common cli...

BACKGROUND Regarding the limited studies about effects of addiction on coagulation factors as a risk factor for increasing coagulation, and its relation to coronary artery disease, we decided to investigate the effect of opium on inflammatory and coagulation factors in a controlled setting. METHODS This case-control study was performed using two groups of smoking males addicted to opium (27 c...

A major challenge presently is not only to identify the genetic polymorphisms increasing risk to diseases, but to also find out factors and mechanisms, which can counteract a risk genotype by developing a resilient phenotype. The objective of this study was to examine acquired and innate vagal mechanisms that protect against physical challenges and haemorrhages in 19 athletes and 61 non-athlete...

Several disorders of coagulation and fibrinolysis have been widely reported in patients with hyperthyroidism. Most reports have focused on only the venous thromboembolism risk, and few of them have studied specifically the association between hyperthyroidism and pulmonary embolism (PE). We report two cases of Graves' disease complicated by PE. The first patient is a 32 year-old man, and the sec...

BACKGROUND Fresh frozen plasma (FFP) should be thawed before transfusing to the patient. Prolonged or uncontrolled thawing can denature plasma proteins. The potential risk of contamination by wet thawing had always been a point of concern. AIMS Here, we compared and evaluated the effect of thawing on clotting factor activities by two different methods (wet and dry) and other factors such as r...