نتایج جستجو برای: coagulation pathway

تعداد نتایج: 358621  

2005
Inger Schousboe

The general hypothesis for the biological function of 112W glycoprotein I is that it neutralizes all negatively charged macromolecules that might enter the bloodstream and diminishes unwanted activation of the blood coagulation. In the present study we report that $2-glycoprotein I inhibits the activation of the contact phase system of the intrinsic pathway of blood coagulation. Activation was ...

2015
Driss El Kebir Anas Damlaj Nesrine Makhezer János G. Filep

OBJECTIVE Bacterial DNA (CpG DNA) persists in tissues and blood under pathological conditions that are associated with enhanced intravascular coagulation. Toll-like receptor 9 recognizes CpG DNA and elicits innate and adoptive immunity, yet the impact of CpG DNA on coagulation has not been studied. In this study, we investigated the effects of CpG DNA on the expression and activity of tissue fa...

ژورنال: مجله علمی پژوهان 2014

Introduction: Coagulation factor X is an important protein in the blood coagulation pathway. It contains significant structural features that affect its function. The purpose of this study was to investigate the structural-functional features of activated form of Factor X in the presence of calcium ions. Factor X consists of 4 domains. Gamma-carboxyl glutamic acid (GLA) domain contains negative...

2017
Chen-Xue Mao Ji-Ye Yin Ying Zhang Zhi-Bin Wang Zhi-Quan Yang Zheng-Wen He Xiang-Min Li Xiao-Yuan Mao Ru-Tao Cui Xue-Jun Li Xi Li Wei Zhang Hong-Hao Zhou Zhao-Qian Liu

Aim This study will explore the genetic and epigenetic alterations in astrocytomas, and identify the critical molecular signatures and signaling pathways for prognosis assessment by multiplatform comprehensive analysis. Method We performed integration analyses of incorporating DNA methylation, mRNA expression, microRNA expression, and long non-coding RNA (lncRNA) expression in 33 astrocytic t...

Journal: :British journal of anaesthesia 2011
J J van Veen D R Spahn M Makris

Routine coagulation tests have been used for many years in the preoperative setting in the belief that they identify patients who may have acquired or congenital bleeding disorders, and on the assumption that testing will predict perioperative bleeding allowing treatment to be given and prevent it. Coagulation ‘screens’ typically include the prothrombin time (PT) and the activated partial throm...

Journal: :Cancer research 1995
E G Fischer W Ruf B M Mueller

The human melanoma cell line M24met expresses tissue factor, the cellular initiator of the blood coagulation cascade. Blocking of the coagulation pathways at the level of tissue factor, factor Xa, or thrombin inhibits hematogenous M24met metastasis in SCID mice, implicating a role for thrombin generation in this process. Dependent on cell surface tissue factor activity, M24met cells generate th...

Journal: :Thrombosis and haemostasis 2013
E P Feener Q Zhou W Fickweiler

Plasma kallikrein (PK) is a serine protease generated from plasma prekallikrein, an abundant circulating zymogen expressed by the Klkb1 gene. The physiological actions of PK have been primarily attributed to its production of bradykinin and activation of coagulation factor XII, which promotes inflammation and the intrinsic coagulation pathway. Recent genetic, molecular, and pharmacological stud...

2010

ASSAY PRINCIPLE: Antithrombin is the major physiological coagulation inhibitor. It inhibits coagulation serine esterases, especially Thrombin, Factor Xa and Factor IXa, regulates coagulation pathway and prevents from thrombosis. In the absence of heparin, Antithrombin is a “slow acting”, progressive, inhibitor of coagulation serine esterases. The antithrombin Anti-IIa method is a method based o...

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