The interference of antibodies to factor VIII coagulant protein (Vlll:C) of 9 nonhemophilic patients with the binding to factor VIII coagulant antigen (VIII:CAg) of a reference hemophilic ‘251-Fab’ reagent, used in a liquid phase Vlll:CAg assay, was studied. The binding competition was estimated from immunoradiometric assay (IRMA) doseresponse slope of Vlll:CAg present in patient plasma. interf...

Blood coagulation could be recognized as intrinsic inflammation. The coagulant mediators (FVIIa, FXa, thrombin (FIIa), FXIIa) and fibrin(ogen) activate cellular signaling, eliciting the production of cytokines, chemokines, growth factors, and other proinflammatory mediators. Hypercoagulability with elevated coagulant mediators would certainly trigger hyper-inflammatory state not to mention abou...

It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and aft...

The massive growth of potentially toxic cyanobacteria in water supply reservoirs, such as Legedadi Reservoir (Ethiopia), poses a huge burden to purification units and represents serious threat public health. In this study, we evaluated the efficiency flocculants/coagulants chitosan, Moringa oleifera seed (MOS), poly-aluminium chloride (PAC) settling cyanobacterial species present Reservoir. We ...

Purpose: To determine the structure of Konjac glucomannan sulfate (KOGMS) including homogeneity, sulfate group composition as well as its anti-coagulant activity in vitro. Methods: KOGMS was prepared using chlorosulfonic acid and N, N-dicyclohexyl carbodiimide (DCC) from konjac oligo-glucomannan (KOGM). Homogeneity analysis was confirmed by cellulose acetate membrane electrophoresis. Fourier tr...

This paper discusses fast yet simple method of treating effluents of textile industry by simple chemicals. Textiles industry produces substantial toxic, often loaded with color (from residues of reactive dyes and chemicals), acidic and alkaline contaminants having high pH, high concentration of organic materials etc, which requires proper treatment before being released into the environment. Re...

Exposure of phosphatidylserine (PS) on the outer leaflet of the cell membrane is thought to play a critical role in tissue factor (TF) decryption. Recent molecular dynamics simulation studies suggested that the TF ectodomain may directly interact with PS. To investigate the potential role of TF direct interaction with the cell surface phospholipids on basal TF activity and the enhanced TF activ...

Platelets have recently been shown to participate in reactions with blood coagulation factors at every stage of intrinsic clotting, from contact activation to fibrin formation. Platelets can trigger intrinsic coagulation by two alternative pathways, the first of which involves factors XII and Xl and adenosine diphosphate, and the second of which bypasses factor XII, provided factor Xl and colla...