A simple, highly sensitive, accurate and selective method for determination of trace amounts of Co(II) in water samples is presented. Isocyanate treated graphite oxides (iGOs) solid phase extraction adsorbent was synthesized by covalently isocyanate onto the surfaces of graphite oxides. The stability of a chemically (iGOs) especially in concentrated hydrochloric acid which was then used as a re...

Sustained release matrix pellets of the freely water soluble drug, betahistine dihydrochloride (BH), were prepared using freeze pelletization technique. Different waxes and lipids (cetyl alcohol, beeswax, glyceryl tripalmitate (GTP) and glyceryl tristearate) were evaluated for the preparation of matrix pellets. A D-optimal design was employed for the optimization and to explore the effect of dr...

(1)H NMR relaxation and diffusion studies were performed on water-in-CO(2) (W/C) microemulsion systems formed with phosphorus fluorosurfactants of bis[2-(F-hexyl)ethyl] phosphate salts (DiF(8)), having different counterions (Na(+), NH(4)(+), N(CH(3))(4)(+)) by means of high-pressure in situ NMR. Water has a low solubility in CO(2) and is mainly solubilized by the microemulsion droplets formed w...

The aim of this investigation was to design and develop nanoemulsions (NEs) as novel ophthalmic delivery systems for brinzolamide (BZD). Phase behavior of quaternary systems composed of triacetin and CapryolTM 90 (selected oils, screened through the solubility studies), various surfactants (namely, Cremophor RH 40, Brij 35, Labrasol and tyloxapol), Transcutol P (as co-surfactant) an...

The available minoxidil formulations for topical application suffer with major drawback having less contact time with the scalp which requires repeated application. Hence, the present study was aimed to investigate the effect of microemulsions and microemulsion based hydrogel systems (MEHs) for increased percutaneous penetration of minoxidil. Minoxidil microemulsions were developed by following...

Abstract: Aim: Hormone responsive breast cancer is the most prevalent worldwide. Letrozole a third-generation aromatase inhibitor widely used for treatment of advanced cancer. The primary objective present work to develop and optimize an injectable solid lipid nanoparticle incorporating letrozole circumvent side-effects marketed conventional formulation thereby improve patient compliance. Mater...

one of the common chronic inflammatory skin diseases is acne vulgaris that affects up to 80% of a teen-age population. the progress of acne lesions is due to colonization of propionibacterium acnes (p .acnes) in hair follicles. treatment of acne includes topical or systemic therapy or combination therapy, with a tendency to perform topical therapy in mild to moderate acne. nanoemulsions, small ...

BACKGROUND Self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polymer that improve bioavailability and increase solubility of poorly-soluble drugs. OBJECTIVES This study was aimed to prepare and develop a stable formulation for self-emulsifying drug delivery system...

Ideal artificial materials such as magnetic thin films and superlattices are expected to possess unique properties owing to their reduced symmetry and dimensionality. In real systems, however, the actual behavior is extremely sensitive to the morphological features of the films and interfaces. {Co/Cu} heterostructures on Cu(111) are a prototypical example: their growth is complicated by several...

PURPOSE The aim of study is to investigate role of co-surfactant in self-emulsification through rheological analysis of intermediate liquid crystalline (LC) phase formed during self-emulsification. METHODS To mixture of Captex 200P (C200) and tween 80 (T80) (SES Plain), either medium hydrocarbon chain co-surfactant (Capmul MCM (CMCM): SES C) or long hydrocarbon chain co-surfactant (Peceol (P)...