Multiple Sclerosis (MS) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. Extracellular Matrix (ECM) have important role in the central nervous system (CNS). Alterations are happening to the ECM after the CNS disorder like MS, Alzheimer and other neural injury. Tenasin-C (TnC) is a glycoprotein that is highly expressed in inflammatory conditions of the CNS...

after central nervous system (cns) injuries, the regeneration process does not work out well except for remyelination process. this remyelination capacity in cns can be mentioned as a worthy example of stem/precursor cell-mediated renewal process. remyelination in cns is mediated by schwann cells which act mainly as remyelinating agents in peripheral nervous system (pns) but several studies hav...

The vascular endothelium is a rich source of plasminogen activator (PA) and thus of blood vessel-associated fibrinolytic activity. Cultured bovine aortic endothelial cells were employed to determine if components of the coagulation system interact with the endothelium to modify expression of this activity. The addition of thrombin to these cultures led to a rapid decline in intracellular PA act...

In the past few years, a renowned interest in interplay between immune system and central nervous systems (CNS) has sparked wealth of new experimental studies. Two recent publications Science shed light on “resident” cell populations CNS their functions homeostasis pathological status, with potential implications understanding disease mechanisms designing “intelligent” therapies.

N ABNORMALITY of the red cells of paroxysmal nocturnal hemoglobinuria ( PNH ) is responsible for their short life span in the circulation anu their lysis in vitro by certain factors present in normal plasma or serum. The hemolytic system in vitro is characteristically more active when the serum is made somewhat acid, about pH 6.8. The addition of thrombin to the serum is also capable of increas...

N ABNORMALITY of the red cells of paroxysmal nocturnal hemoglobinuria ( PNH ) is responsible for their short life span in the circulation anu their lysis in vitro by certain factors present in normal plasma or serum. The hemolytic system in vitro is characteristically more active when the serum is made somewhat acid, about pH 6.8. The addition of thrombin to the serum is also capable of increas...

Tsopanoglou, Nikos E., Paraskevi Andriopoulou, and Michael E. Maragoudakis. On the mechanism of thrombin-induced angiogenesis: involvement of v 3-integrin. Am J Physiol Cell Physiol 283: C1501–C1510, 2002. First published July 17, 2002; 10.1152/ajpcell.00162.2002.— Thrombin has been reported to be a potent angiogenic factor both in vitro and in vivo, and many of the cellular effects of thrombin...

Bone morphogenetic protein 9 (BMP9), also known as growth differentiation factor 2 (GDF2), is a member of the transforming ? (TGF ?) superfamily. Although BMP9 plays pivotal roles during development, including angiogenesis, hematopoiesis, hepatogenesis, osteogenesis, and glucose metabolism, little information available for expression in central nervous system (CNS). We, thus, investigated adult...

Background. The extracellular matrix of the PNS/CNS is unusual in that it dominated by glycosaminoglycans, especially hyaluronan, whose space filling and hydrating properties make essential contributions to functional this tissue. Hyaluronan has a relatively simple structure but its space-filling ensure micro-compartments are maintained brain ultrastructure, ensuring ionic niches gradients for ...

neurocysticercosis, is the infection caused by the larval form of the tapeworm taenia solium. it is considered as the most common parasitic disease of the central nervous system and the most common cause of acquired epilepsy. this has primarily been a disease that remains endemic in countries with poor economy , but because of increased migration neurocysticercosis is being diagnosed more frequ...