Perispinal injection is a novel emerging method of drug delivery to the central nervous system (CNS). Physiological barriers prevent macromolecules from efficiently penetrating into the CNS after systemic administration. Perispinal injection is designed to use the cerebrospinal venous system (CSVS) to enhance delivery of drugs to the CNS. It delivers a substance into the anatomic area posterior...

Intranasal route of administration shows potential for delivery of drugs to brain. The nose-to-brain drug delivery of drugs is advantageous as it requires low dose of drug, avoids first pass effect. Also it is fast in action and suitable for the drugs that degrade in gastrointestinal tract. Nose-to-brain delivery also avoids blood brain barrier which is important factor to be considered in form...

Background/introduction The delivery of systemically administered drugs and genes to the CNS is hindered by both the blood-brain barrier (BBB), which limits transport from the bloodstream to the brain to only a few privileged molecules, and the nanoporous electrostatically charged tissue space, denoted here as the “brain tissue barrier” (BTB). Our group engineers targeted drug and gene delivery...

Targeted drug delivery systems have been used to deliver drugs in the disease sites of the body. This may reduce potential side effects of drugs and improve their therapeutic effects. Development of brain targeting drug delivery system help in the treatment of disorders related to brain. The most challenging research topic in pharmaceutical sciences is brain targeting drug delivery system. Most...

The goal of brain drug targeting technology is the delivery therapeutics across blood barrier (BBB), including human BBB. Nose to has received a great deal attention as non- invasive, convenient and reliable system. For systemic targetedadministration drug. various deliveries through some transport pathways, Factor influencing nasal absorption, formulation strategies nose brain, colloidal carri...

The blood-brain barrier (BBB) is a major obstacle to drug delivery into the central nervous system (CNS), in particular for macromolecules such as peptides and proteins. However, certain macromolecules can reach the CNS via a receptor-mediated transcytosis (RMT) pathway, and low-density lipoprotein receptor-related protein 1 (LRP1) is one of the promising receptors for RMT. An LRP1 ligand pepti...

The blood-brain barrier is the capillary endothelium between blood and brain that controls what goes in and comes out of the cNs. one major factor contributing to barrier function is a group of ATP-binding cassette (ABC) drug efflux transporters that restrict brain uptake of xenobiotics including a large number of cNs therapeutics. recent research has focused on the regulation of these transpor...

The complexity and organization of the central nervous system (CNS) is widely modulated by presence blood–brain barrier (BBB) blood–cerebrospinal fluid (BCSFB), which both act as biochemical, dynamic obstacles impeding any type undesirable exogenous exchanges. disruption these barriers usually associated with development neuropathologies can be consequence genetic disorders, local antigenic inv...